"Systematic pan-cancer analysis identifies transmembrane protein 158 as a potential therapeutic, prognostic and immunological biomarker"

作者全名："Li, Jiayi; Hou, Haiguang; Sun, Jinhao; Ding, Zhaoxi; Xu, Yingkun; Li, Guibao"

作者地址："[Li, Jiayi] Shandong Univ, Sch Management, Jinan 250100, Shandong, Peoples R China; [Hou, Haiguang; Sun, Jinhao; Ding, Zhaoxi; Li, Guibao] Shandong Univ, Sch Basic Med Sci, Dept Anat, Jinan 250012, Shandong, Peoples R China; [Xu, Yingkun] Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing 400016, Peoples R China; [Li, Jiayi] Hanyang Univ, Sch Grad, Seoul 04763, South Korea"

通信作者："Li, GB (通讯作者)，Shandong Univ, Sch Basic Med Sci, Dept Anat, Jinan 250012, Shandong, Peoples R China."

来源：FUNCTIONAL & INTEGRATIVE GENOMICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000961969000001

JCR分区：Q1

影响因子：3.9

年份：2023

卷号：23

期号：2

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结束页：　

文献类型：Article

关键词：TCGA; TMEM158; Therapeutic target; Immune infiltration; Pan-cancer analysis

摘要："The purpose of this study was to investigate the expression significance, predictive value, immunologic function, and biological role of transmembrane protein 158 (TMEM158) in the development of pan-cancer. To achieve this, we utilized data from multiple databases, including TCGA, GTEx, GEPIA, and TIMER, to collect gene transcriptome, patient prognosis, and tumor immune data. We evaluated the association of TMEM158 with patient prognosis, tumor mutational burden (TMB), and microsatellite instability (MSI) in pan-cancer samples. We performed immune checkpoint gene co-expression analysis and gene set enrichment analysis (GSEA) to better understand the immunologic function of TMEM158. Our findings revealed that TMEM158 was significantly differentially expressed between most types of cancer tissues and their adjacent normal tissues and was associated with prognosis. Moreover, TMEM158 was significantly correlated with TMB, MSI, and tumor immune cell infiltration in multiple cancers. Co-expression analysis of immune checkpoint genes showed that TMEM158 was related to the expression of several common immune checkpoint genes, especially CTLA4 and LAG3. Gene enrichment analysis further revealed that TMEM158 was involved in multiple immune-related biological pathways in pan-cancer. Overall, this systematic pan-cancer analysis suggests that TMEM158 is generally highly expressed in various cancer tissues and is closely related to patient prognosis and survival across multiple cancer types. TMEM158 may serve as a significant predictor of cancer prognosis and modulate immune responses to various types of cancer."

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