Survival prediction among pathologic T4 bladder cancer patients following cytoreductive cystectomy: A retrospective single-center study

作者全名："Bai, Xuesong; Chen, Guo; Shang, Shihai; Li, Senlin; Liu, Huanrui; Feng, Zhenwei; Gou, Xin"

作者地址："[Bai, Xuesong; Chen, Guo; Li, Senlin; Liu, Huanrui; Feng, Zhenwei; Gou, Xin] Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, Chongqing, Peoples R China; [Shang, Shihai] Wansheng Peoples Hosp, Dept Urol, Chongqing, Peoples R China"

通信作者："Gou, X (通讯作者)，Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN SURGERY

ESI学科分类：　

WOS号：WOS:000963078700001

JCR分区：Q2

影响因子：1.6

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：bladder cancer; pT4; cystectomy; age-adjusted charlson comorbidity index; prognosis

摘要："ObjectivesThis retrospective study aimed to describe our institutional experience with cytoreductive cystectomy (Cx) in patients with pathological T4 (pT4) bladder cancer (BCa) and to investigate the clinicopathologic factors that can predict patient survival outcomes. MethodsWe reviewed the baseline demographics, clinicopathologic features, perioperative complications, and follow-up data of 44 patients who underwent Cx for pT4 BCa at our institution between 2013 and 2021. The Kaplan-Meier curve and the log-rank test were used to analyze progression-free survival (PFS) and overall survival (OS). Univariate and multivariate analyses were performed using the Cox regression model. ResultsThe median age of the patients was 68 years [95% confidence interval (CI) 49-81]. Overall, 21 patients (47.7%) were estimated to have a high age-adjusted Charlson comorbidity index (ACCI) score (>4), and nine patients (20.5%) had pT4b substage BCa. None of the patients died of complications within 30-90 days after surgery. Severe complications occurred in 16% (n = 7) of patients within 30-90 days. During a median follow-up of 51 months, disease progression was detected in 25 patients (56.8%), and 29 patients (65.9%) died of any cause. The median PFS and OS were 15.0 and 21.0 months, respectively. The Kaplan-Meier analysis indicated that patients with high ACCI scores or pT4b BCa had worse PFS (P = 0.003 and P = 0.002, respectively) and OS (P = 0.016 and P = 0.034, respectively) than those with low ACCI scores or pT4a BCa. On multivariate analysis, pT4b substage [hazard ratio (HR), 4.166; 95% CI, 1.549-11.206; P = 0.005] and ACCI score >4 (HR, 2.329; 95% CI, 1.105-4.908; P = 0.026) remained independent risk factors for PFS and OS, respectively. ConclusionOur study revealed that the pT4b substage is associated with a poor prognosis and that the ACCI score is a relevant and practical method to evaluate survival outcomes in patients with pT4 BCa after Cx."

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