FMRP binds Per1 mRNA and downregulates its protein expression in mice

作者全名："Tang, Xiangrong; Zhang, Jing; Li, Xin; Hu, Ying; Liu, Dengfeng; Li, Jia-Da; Lu, Renbin"

作者地址："[Tang, Xiangrong; Lu, Renbin] Cent South Univ, Xiangya Hosp, Hunan Key Lab Mol Precis Med, Changsha, Peoples R China; [Tang, Xiangrong; Zhang, Jing; Li, Xin; Hu, Ying; Liu, Dengfeng; Li, Jia-Da; Lu, Renbin] Cent South Univ, Ctr Med Genet, Sch Life Sci, Changsha 410078, Hunan, Peoples R China; [Tang, Xiangrong] Chongqing Med Univ, Ctr Reprod Med, Women & Childrens Hosp, Chongqing 400010, Peoples R China; [Li, Jia-Da; Lu, Renbin] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geratr Disorder, Changsha 410008, Peoples R China; [Lu, Renbin] Changsha Med Univ, Dept Basic Med Sci, Changsha, Peoples R China"

通信作者："Lu, RB (通讯作者)，Cent South Univ, Xiangya Hosp, Hunan Key Lab Mol Precis Med, Changsha, Peoples R China.; Li, JD; Lu, RB (通讯作者)，Cent South Univ, Ctr Med Genet, Sch Life Sci, Changsha 410078, Hunan, Peoples R China.; Li, JD; Lu, RB (通讯作者)，Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geratr Disorder, Changsha 410008, Peoples R China.; Lu, RB (通讯作者)，Changsha Med Univ, Dept Basic Med Sci, Changsha, Peoples R China."

来源：MOLECULAR BRAIN

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000963363200001

JCR分区：Q2

影响因子：3.3

年份：2023

卷号：16

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：FXS; FMRP; Circadian rhythm; Per1

摘要："FMRP, an RNA-binding protein, has previously shown to be involved in regulation of circadian rhythms in flies and mice. However, the molecular mechanism remains elusive. Here we demonstrate that core circadian component Per1 mRNA was a target of FMRP and the association leads to reduced PER1 expression. In Fmr1 KO mice, the oscillation of PER1 protein expression was significantly affected in a temporal and tissue-dependent pattern when compared to WT mice. Our work thus identified Per1 mRNA as a novel target of FMRP and suggested a potential role of FMRP in regulation of circadian function."

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