Bone regeneration strategies based on organelle homeostasis of mesenchymal stem cells

作者全名："Xin, Liangjing; Wen, Yao; Song, Jinlin; Chen, Tao; Zhai, Qiming"

作者地址："[Xin, Liangjing; Wen, Yao; Song, Jinlin; Chen, Tao; Zhai, Qiming] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China; [Xin, Liangjing; Wen, Yao; Song, Jinlin; Chen, Tao; Zhai, Qiming] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China"

通信作者："Song, JL; Chen, T; Zhai, QM (通讯作者)，Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China.; Song, JL; Chen, T; Zhai, QM (通讯作者)，Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000963492100001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：mesenchymal stem cells; osteogenesis; subcellular homeostasis; target strategies; organelle regulation

摘要："The organelle modulation has emerged as a crucial contributor to the organismal homeostasis. The mesenchymal stem cells (MSCs), with their putative functions in maintaining the regeneration ability of adult tissues, have been identified as a major driver to underlie skeletal health. Bone is a structural and endocrine organ, in which the organelle regulation on mesenchymal stem cells (MSCs) function has most been discovered recently. Furthermore, potential treatments to control bone regeneration are developing using organelle-targeted techniques based on manipulating MSCs osteogenesis. In this review, we summarize the most current understanding of organelle regulation on MSCs in bone homeostasis, and to outline mechanistic insights as well as organelle-targeted approaches for accelerated bone regeneration."

基金机构："National Natural Science Foundation of China [82201059, 32071362]; Chongqing Post-doctoral Science Special Foundation [2021XM1031]; Natural Science Foundation of Chongqing, China [2022NSCQ-BHX0033]"

基金资助正文："Funding This work was supported by the National Natural Science Foundation of China (82201059, 32071362), the Chongqing Post-doctoral Science Special Foundation (2021XM1031), the Natural Science Foundation of Chongqing, China (2022NSCQ-BHX0033)."