The Impact of Bariatric Surgery on Pancreatic Cancer Risk: a Systematic Review and Meta-Analysis

作者全名："Fan, Hongdan; Mao, Qingsong; Zhang, Wenfeng; Fang, Qinghua; Zou, Qu; Gong, Jianping"

作者地址："[Fan, Hongdan; Mao, Qingsong; Zhang, Wenfeng; Zou, Qu; Gong, Jianping] Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing 400010, Peoples R China; [Fang, Qinghua] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing 400010, Peoples R China"

通信作者："Gong, JP (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing 400010, Peoples R China."

来源：OBESITY SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000963713100001

JCR分区：Q1

影响因子：2.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Bariatric surgery; Pancreatic cancer; Risk reduction; Obesity

摘要："A growing body of evidence suggests that bariatric surgery is associated with a reduced risk of some cancers. This meta-analysis aims to determine whether bariatric surgery affects pancreatic cancer risk. We conducted a comprehensive literature search of PubMed, Embase, and Web of Science databases. Fixed-effect models were used to estimate pooled data and presented as odds ratio (OR) and 95% confidence interval (CI). Heterogeneity was assessed using the Cochran Q test and I-2 test. A total of 9 cohort studies involving 1,147,473 patients were included in the analysis. The pooled OR was 0.76 (95% CI = 0.64-0.90). The Cochran Q test and I-2 test indicated only mild heterogeneity (P = 0.12, I-2 = 38%). In the subgroup analyses, the pooled OR was 0.67 (95% CI = 0.54-0.82) for North America. In the subgroup analyses by mean follow-up time, the pooled OR was 0.46 (95% CI = 0.28-0.74) for less than 5 years. In conclusion, bariatric surgery has a positive effect on pancreatic cancer reduction, especially in North America. This effect may diminish or disappear with time."

基金机构：China Postdoctoral Science Foundation [2019M653352]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University

基金资助正文：This work was supported by grants from China Postdoctoral Science Foundation (2019M653352) and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University.