RHBDF2 is correlated with immune infiltrates in hepatocellular carcinoma and may have potential as a biomarker

作者全名："Gong, Hanjuan; Xie, Hailun; Huangfu, Zhimin; Zhang, Shuxian; Tang, Yi; Xiao, Ming; Li, Ming; Wang, Yalan"

作者地址："[Gong, Hanjuan; Xie, Hailun; Huangfu, Zhimin; Zhang, Shuxian; Tang, Yi; Xiao, Ming; Li, Ming; Wang, Yalan] Chongqing Med Univ, Basic Med Coll, Mol Med & Canc Res Ctr, Dept Pathol, Chongqing, Peoples R China; [Wang, Yalan] Chongqing Med Univ, Basic Med Coll, Mol Med & Canc Res Ctr, Dept Pathol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Wang, YL (通讯作者)，Chongqing Med Univ, Basic Med Coll, Mol Med & Canc Res Ctr, Dept Pathol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：FEBS OPEN BIO

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000963969400001

JCR分区：Q3

影响因子：2.8

年份：2023

卷号：13

期号：5

开始页：881

结束页：897

文献类型：Article

关键词：bioinformatics analysis; hepatocellular carcinoma; immune infiltration; prognostic biomarker; RHBDF2

摘要："Immune checkpoint inhibitors have been approved for the treatment of advanced hepatocellular carcinoma (HCC). However, immunotherapy requires the identification of suitable biomarkers to guide treatment. The gene for rhomboid 5 homolog 2 (IRHom2), which encodes the rhombus protease iRhom2, activates the MAP3K7-dependent pathway and promotes hepatic steatosis. Thus, we hypothesized an involvement of this gene in HCC. We report that RHBDF2 expression is dramatically upregulated in HCC. RHBDF2 upregulation is associated with tumor stage, lymph node metastasis, tumor protein P53 mutation, and worse prognoses in HCC patients. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes and gene set enrichment analysis enrichment analysis indicated that RHBDF2 was involved in immune signal pathways. Moreover, RHBDF2 expression was positively related not only to immune infiltration, but also to immune cell markers. Examination of several types of HCC infiltrated by immune cells revealed that the group with high expression of RHBDF2 showed the worst outcomes. Therefore, RHBDF2 may have potential as a novel biomarker for predicting prognosis and is related to immune infiltrates in HCC."

基金机构：Innovation Project of Graduate Student in Chongqing [CYB17100]; National Nature Science Foundation of China [30870946]; Science and Technology Research Foundation of Chongqing Municipal Education Commission [KJQN201800435]

基金资助正文："Acknowledgments The work was supported by the Innovation Project of Graduate Student in Chongqing (CYB17100), the National Nature Science Foundation of China (30870946), and the Science and Technology Research Foundation of Chongqing Municipal Education Commission (KJQN201800435)."