Inulin alleviates offspring asthma by altering maternal intestinal microbiome composition to increase short-chain fatty acids

作者全名："Yuan, Guifang; Wen, Song; Zhong, Xuemei; Yang, Xiaotong; Xie, Linrui; Wu, Xiuli; Li, Xiaoyu"

作者地址："[Yuan, Guifang; Yang, Xiaotong] Chongqing Med Univ, Dept Clin Med 1, Chongqing, Peoples R China; [Wen, Song] Peking Univ Canc Hosp & Inst, Familial & Hereditary Canc Ctr, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing, Peoples R China; [Zhong, Xuemei] Chongqing Med & Pharmaceut Coll, Sch Clin Med, Dept Resp Endocrinol, Chongqing, Peoples R China; [Xie, Linrui] Chongqing Med Univ, Dept Clin Med 2, Chongqing, Peoples R China; [Wu, Xiuli] Ninth Peoples Hosp Chongqing, Chongqing, Peoples R China; [Li, Xiaoyu] Chongqing Med Univ, Basic Med Expt Teaching Ctr, Lab Innovat, Chongqing, Peoples R China"

通信作者："Wu, XL (通讯作者)，Ninth Peoples Hosp Chongqing, Chongqing, Peoples R China.; Li, XY (通讯作者)，Chongqing Med Univ, Basic Med Expt Teaching Ctr, Lab Innovat, Chongqing, Peoples R China."

来源：PLOS ONE

ESI学科分类：Multidisciplinary

WOS号：WOS:000968026400029

JCR分区：Q1

影响因子：2.9

年份：2023

卷号：18

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Technically, symptom of offspring asthma is also closely reliant on its maternal high-fiber diet as well as the intestinal microbiome. Fruits and vegetables are abundant in inulin, and this naturally soluble dietary fiber is endowed with a potential value on offspring asthma control through the maternal intake, but the mechanism now remains less studied. In this study, rats were given with inulin-included drinking water, whereas in normal group rats were allowed with normal water. Afterwards, we analyzed both the formations of the offspring intestinal microbiome ahead of asthma model establishment and of the maternal intestinal microbiome through high throughput sequence and the short-chain fatty acids (SCFAs) by metabolomic analysis. Subsequently, lung inflammation indexes were detected by Elisa, and the expression of short-chain fatty acid receptors (GPR41, GPR43) in the offspring of asthma models were evaluated through qPCR assay. Inulin intake resulted in altered maternal intestinal microbiome composition, with a significant increase in SCFAs-producing bacteria (mainly Bifidobacterium), attenuating the asthmatic inflammatory response in the offspring. Meanwhile, inulin intake during pregnancy modulates the composition of the intestinal microbiome of the offspring, and this alteration appears before the onset of asthma, hence, there should be further studies onto the impacts of offspring's intestinal microbiome on asthma procession."

基金机构：Scientific Research and Innovation Experiment Project of Chong-qing Medical University [202001]; Student Innovation and Entrepreneurship Program of China [:202010631001]

基金资助正文："This research was funded by Scientific Research and Innovation Experiment Project of Chong-qing Medical University (grant number 202001, www.cqmu.edu.cn)and The Student Innovation and Entrepreneurship Program of China (Grant Number:202010631001, http://gjcxcy.bjtu.edu.cn/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."