Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years

作者全名："Ma, Zhuoying; Chen, Lin; Xian, Ruoling; Fang, Heping; Chen, Jing; Li, Haiqi; Wang, Juan; Hu, Yan"

作者地址："[Ma, Zhuoying; Chen, Lin; Xian, Ruoling; Fang, Heping; Chen, Jing; Li, Haiqi; Wang, Juan; Hu, Yan] Chongqing Med Univ, Dept Child Hlth Care, Childrens Hosp, Chongqing, Peoples R China; [Ma, Zhuoying; Chen, Lin; Xian, Ruoling; Fang, Heping; Chen, Jing; Li, Haiqi; Wang, Juan; Hu, Yan] Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Chongqing Key Lab Child Hlth & Nutr, Chongqing, Peoples R China"

通信作者："Hu, Y (通讯作者)，Chongqing Med Univ, Dept Child Hlth Care, Childrens Hosp, Chongqing, Peoples R China.; Hu, Y (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Chongqing Key Lab Child Hlth & Nutr, Chongqing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000968058500001

JCR分区：Q1

影响因子：7.3

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：children; food sensitization; risk factor; change; early life

摘要："BackgroundAlthough epidemiological trends of childhood food sensitization (FS) in IgE-mediated food allergy were reported in China, few studies have examined at changes in its risk factors. ObjectiveTo investigate the change in early-life risk factors associated with childhood food sensitization during 2009-2019 in China. MethodsData from two cross-sectional surveys conducted in 2009 and 2019 (401 and 513 children, respectively) were analyzed. The results of skin prick tests and information on food sensitization-related risk factors in children were summarized, including family history of atopic disease (FHA), demographic characteristics, method of delivery, feeding patterns, sibship size, pet ownership, and vitamin D supplementation. Binary logistic regression was used to calculate the odds ratio and the regression coefficient beta-value of risk factors in the 2009 and 2019 surveys separately. Then, coefficient beta-value differences between the two surveys were analyzed by the bdiff command in STATA to describe the change in risk factors over 10 years. ResultsThe 2009 survey revealed that FHA, age, only child, and feeding patterns were associated with food sensitization. The 2019 survey showed that food sensitization was affected by age, sex, and feeding patterns. However, from 2009 to 2019, the probability of food sensitization in the only-child group significantly increased by 226.0% (beta-value difference = 0.81, P = 0.024) and decreased by 65.0% in female children (beta-value difference = -1.06, P = 0.008). The effect of age on food sensitization decreased by 50.0% (beta-value difference = -0.69, P < 0.001) over 10 years. ConclusionThe effect of FHA and common lifestyle factors on food sensitization did not significantly change during 2009-2019. However, the influence of demographic characteristics on food sensitization has changed since 2009; that is, older age, male gender, and only child are more likely to develop food sensitization, which needs to be considered in future epidemiological surveys."

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