"Analysis of Characteristics, Pathogens and Drug Resistance of Urinary Tract Infection Associated with Long-Term Indwelling Double-J Stent"

作者全名："Li, Yuehua; Jiang, Li; Luo, Shengjun; Hu, Daixing; Zhao, Xin; Zhao, Guozhi; Tang, Wei; Guo, Yu"

作者地址："[Li, Yuehua] Chongqing Med Univ, University Town Hosp, Dept Urol, Chongqing 400000, Peoples R China; [Jiang, Li; Luo, Shengjun; Hu, Daixing; Zhao, Xin; Zhao, Guozhi; Tang, Wei] Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, Chongqing 400000, Peoples R China; [Guo, Yu] Chongqing Tradit Chinese Med Hosp, Dept Urol, Chongqing 400000, Peoples R China"

通信作者："Guo, Y (通讯作者)，Chongqing Tradit Chinese Med Hosp, Dept Urol, Chongqing 400000, Peoples R China."

来源：INFECTION AND DRUG RESISTANCE

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000968273600001

JCR分区：Q2

影响因子：2.9

年份：2023

卷号：16

期号：　

开始页：2089

结束页：2096

文献类型：Article

关键词：double-J stent; biofilm; pathogens; urinary tract infection; drug resistance; drug resistant bacteria; infection

摘要："Objective: To investigate the characteristics, pathogens and drug resistance of urinary tract infection (UTI) associated with long-term indwelling double-J stent. Methods: The clinical data of 102 patients with urinary tract infection associated with long-term indwelling double-J stent in University-Town Hospital of Chongqing Medical University and Chongqing Traditional Chinese Medicine Hospital from September 2010 to July 2022 were collected retrospectively, and the difference between etiological characteristics were analyzed. Urine and double-J stent samples of patients were collected for pathogen identification and drug sensitivity test. Results: A total of 102 patients, 39 (38.23%) males and 63 (61.77%) females, aged 24-72 years, with a median age of 48 years, were included in this study. Urinary calculi (40.20%) and ureteral stricture (24.50%) were the main causes of urinary tract infection associated with long-term indwelling double-J stent. Among the patients with urinary tract infection caused by double-J stent, female patients were higher than male patients (61.77% vs 38.23%). In terms of positive rate of pathogenic bacteria culture, the rate of double-J stent was higher than that of urine (67.65% vs 35.29%). The main pathogenic bacteria in urine were Escherichia coli (30.55%) of Gram negative bacteria, while the main pathogenic bacteria in double-J stent were enterococcus faecalis (27.53%) of Gram positive bacteria. The resistance rate of Gram positive bacteria in double-J stent to vancomycin, ciprofloxacin, meropenem and piperacillin/ tazobactam was significantly higher than that in urine (P<0.05). The resistance rate of Gram negative bacteria in double-J stent to imipenem, cefepime, piperacillin/tazobactam, meropenem and cefoperazone/sulbactam was significantly higher than that in urine (P<0.05). Conclusion: Double-J stent associated urinary tract infection is more common in women than in men. Escherichia coli and Enterococcus faecalis are the main pathogens, and the pathogens show strong drug resistance."

基金机构：Chongqing medical scientific research project (Chongqing Health Commission) [2023MSXM158]; Chongqing medical scientific research project (Science and Technology Bureau) [2023MSXM158]

基金资助正文："This work was supported by Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) , Fund No. 2023MSXM158."