Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data

作者全名："Liu, Lin; Xue, Yuzhou; Chen, Yangmei; Chen, Tingqiao; Zhong, Judan; Shao, Xinyi; Chen, Jin"

作者地址："[Liu, Lin; Chen, Yangmei; Chen, Tingqiao; Zhong, Judan; Shao, Xinyi; Chen, Jin] Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, Chongqing, Peoples R China; [Xue, Yuzhou] Peking Univ Third Hosp, Dept Cardiol, Beijing, Peoples R China; [Xue, Yuzhou] Peking Univ Third Hosp, Inst Vasc Med, Beijing, Peoples R China"

通信作者："Chen, J (通讯作者)，Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:000968300400001

JCR分区：Q2

影响因子：3

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：acne; mental disorders; Mendelian randomization; GWAS; schizophrenia

摘要："BackgroundDespite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies. MethodsWe performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on the risk of six common mental disorders, i.e., depression, anxiety, schizophrenia, obsessive-compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD). We acquired genetic instruments for assessing acne from the largest genome-wide association study (GWAS) of acne (N = 615,396) and collected summary statistics from the largest available GWAS for depression (N = 500,199), anxiety (N = 17,310), schizophrenia (N = 130,644), OCD (N = 9,725), bipolar disorder (N = 413,466), and PTSD (N = 174,659). Next, we performed the two-sample MR analysis using four methods: inverse-variance weighted method, MR-Egger, weighted median, and MR pleiotropy residual sum and outliers. Sensitivity analysis was also performed for heterogeneity and pleiotropy tests. ResultsThere was no evidence of a causal impact of acne on the risk of depression [odds ratio (OR): 1.002, p = 0.874], anxiety (OR: 0.961, p = 0.49), OCD (OR: 0.979, p = 0.741), bipolar disorder (OR: 0.972, p = 0.261), and PTSD (OR: 1.054, p = 0.069). Moreover, a mild protective effect of acne against schizophrenia was observed (OR: 0.944; p = 0.033). ConclusionThe increased prevalence of mental disorders observed in patients with acne in clinical practice was caused by modifiable factors, and was not a direct outcome of acne. Therefore, strategies targeting the elimination of potential factors and minimization of the occurrence of adverse mental events in acne should be implemented."

基金机构：National Natural Science Foundation of China [82073462]

基金资助正文：This study was supported by National Natural Science Foundation of China (n 82073462).