"Enzyme-linked immunospot assay and metagenomic sequencing of Mycobacterium tuberculosis, coagulopathy symptoms, and pancytopenia testing for characterization of pulmonary tuberculosis: case report and literature review"

作者全名："Liu, Helei; Xia, Hong; Jia, Bei; Wu, Jing"

作者地址："[Liu, Helei; Xia, Hong; Wu, Jing] Peoples Hosp Dazu, Dept Infect Dis, Chongqing 402360, Peoples R China; [Jia, Bei] Chongqing Med Univ, Affiliated Hosp 1, Dept Infect Dis, Key Lab Infect & Parasit Dis Chongqing, Chongqing 400016, Peoples R China"

通信作者："Wu, J (通讯作者)，Peoples Hosp Dazu, Dept Infect Dis, Chongqing 402360, Peoples R China.; Jia, B (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Infect Dis, Key Lab Infect & Parasit Dis Chongqing, Chongqing 400016, Peoples R China."

来源：CELLULAR AND MOLECULAR BIOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000969323200027

JCR分区：Q4

影响因子：1.6

年份：2022

卷号：68

期号：10

开始页：178

结束页：181

文献类型：Review

关键词：Tuberculosis; pulmonary tubercu-losis; coagulation; pancytopenia

摘要："Pulmonary Tuberculosis (TB) is common in China, but tuberculosis with coagulation disorders and pancy-topenia have rarely been reported in the past. In this report presented, a 70-year-old female was admitted to the hospital with poor appetite, dark urine, nausea, vomiting, fatigue, and bilateral lower limb edema; chest CT suggested diffuse infectious lesions in both lungs, coagulation dysfunction, and complete pancytopenia, which was initially considered to be caused by severe infection. However, the patient's symptoms did not improve by potent empiric antibiotics treatment, and a repeat chest CT showed that the lung lesions deterio-rated more than before, and coagulation disorders and pancytopenia did not improve. Finally, the TB patient tested positive for enzyme-linked immunospot assay (ELISPOT) and metagenomic sequencing (mNGS) of Mycobacterium tuberculosis (MTB) using bronchoscopic alveolar lavage. So ati-TB was initiated with HRftELfx (isoniazid, 0.3 g qd; rifapentine, 0.45 g biw; ethambutol, 0.75 g qd; and levofloxacin, 0.5 g qd) regimen. Eventually, the patient's clinical symptoms improved significantly, the pulmonary lesions were absorbed, and the coagulation function and blood cell count returned to normal, which achieved a satisfac-tory treatment effect."

基金机构：Chongqing Science and Health Joint Medical Scientific Research Project [2018GDRC002]

基金资助正文：Fundings The research is supported by: Chongqing Science and Health Joint Medical Scientific Research Project (No. 2018GDRC002) .