Elastase-activated ratiometric fluorescent probe as an indicator of inflammatory response

作者全名："Cao, Ting; Zhang, Liang; Liu, Yun; Ma, Hong"

作者地址："[Cao, Ting] Shanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Magnet Mol & Magnet Informat Mat, Minist Educ, Taiyuan 030031, Peoples R China; [Zhang, Liang; Liu, Yun] Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, Chongqing 400010, Peoples R China; [Ma, Hong] Taiyuan Normal Univ, Coll Chem & Mat, Jinzhong 030619, Peoples R China"

通信作者："Cao, T (通讯作者)，Shanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Magnet Mol & Magnet Informat Mat, Minist Educ, Taiyuan 030031, Peoples R China.; Liu, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, Chongqing 400010, Peoples R China."

来源：DYES AND PIGMENTS

ESI学科分类：CHEMISTRY

WOS号：WOS:000969734200001

JCR分区：Q1

影响因子：4.1

年份：2023

卷号：211

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Neutrophil elastase; Near-infrared ratiometric; Fluorescent sensor; Inflammation imaging

摘要："The expression level of neutrophil elastase (NE) is closely related to the occurrence of inflammation. This enzyme has been identified as a research target for the development of anti-inflammatory drugs and for the early diagnosis and treatment of many diseases. This work developed the first near-infrared ratiometric fluorescence sensor (TMNF) for monitoring and imaging NE in vivo and in vitro. Cell imaging results showed that NE was highly expressed in cells treated with pro-inflammatory factors, whereas NE activity was significantly reduced after pretreatment with the enzyme inhibitor. Relevant experiments have shown that inflammation can lead to increased expression of NE in vivo. The imaging of the probe in inflammation mouse shows excellent practicality, making the probe an effective tool for the early diagnosis and treatment of diseases related to inflammatory lesions."

基金机构："Scientific and Technological Inno-vation Programs of Higher Education Institutions in Shanxi [2022L256, 2022L398]"

基金资助正文："Acknowledgments This work was supported by the Scientific and Technological Inno-vation Programs of Higher Education Institutions in Shanxi (No. 2022L256, and No. 2022L398) ."