CD71/CD44 dual-aptamer-gemcitabine conjugate for tumor co-targeting treatment of bladder cancer

作者全名："Liu, Biao; Wang, Jinrong; Peng, Yongbo; Zeng, Hongliang; Zhang, Qun; Deng, Minhua; Xiang, Wei; Liu, Jiahao; Hu, Xing; Liu, Xuewen; Xie, Jianfei; Hou, Weibin; Tang, Jin; Long, Zhi; Wang, Long; Liu, Jianye"

作者地址："[Liu, Biao; Wang, Jinrong; Xiang, Wei; Liu, Jiahao; Hu, Xing; Hou, Weibin; Tang, Jin; Long, Zhi; Wang, Long; Liu, Jianye] Cent South Univ, Dept Urol, Xiangya Hosp 3, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China; [Peng, Yongbo] Chongqing Med Univ, Coll Pharm, Chongqing Key Lab Pharmaceut Metab Res, Key Lab Biochem & Mol Pharmacol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Zeng, Hongliang] Hunan Acad Chinese Med, Ctr Med Lab Anim, Changsha 410013, Hunan, Peoples R China; [Zhang, Qun] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Radiotherapy, 58 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China; [Deng, Minhua] Sun Yat Sen Univ, Dept Urol, Canc Ctr, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China; [Deng, Minhua] Collaborat Innovat Ctr Canc Med, State Key Lab Oncol Southern China, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China; [Liu, Xuewen] Cent South Univ, Dept Onol, Xiangya Hosp 3, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China; [Xie, Jianfei] Cent South Univ, Dept Nursing, Xiangya Hosp 3, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China"

通信作者："Liu, JY (通讯作者)，Cent South Univ, Dept Urol, Xiangya Hosp 3, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China."

来源：CHEMICAL ENGINEERING JOURNAL

ESI学科分类：ENGINEERING

WOS号：WOS:000969924800001

JCR分区：Q1

影响因子：13.3

年份：2023

卷号：464

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Dual-aptamer; Cancer stem cells; Targeted therapy; Drug delivery

摘要："Conventional chemotherapy lacks the ability to specifically target cancer cells, thus although it eliminates tumor tissues to some extent, it also damages normal tissues and organs. Meanwhile, cancer stem cells (CSCs)-induced tumor regrowth and drug resistance limits the application of some chemotherapy drugs. In this study, the CD71/ CD44 dual-aptamer-gemcitabine (CD71-CD44-GEMs) conjugate was designed to treat bladder cancer through the co-targeting by CD71 of bladder cancer cells and by CD44 of bladder CSCs. A series of studies were used to evaluate the binding specificity and the in vitro and in vivo anti-cancer effects. We observed that CD71-CD44GEMs selectively bound to and exerted a high inhibitory effect on bladder cancer in vitro and in vivo. Besides, CD71-CD44-GEMs can inhibit the formation of the tumorsphere and demonstrated a higher binding affinity and inhibitory efficacy than CD71-GEMs or CD44-GEMs (GEM delivered by a single target aptamer) in bladder cancer. Hence, CD71-CD44-GEMs represents a promising approach to treating bladder cancer for its high efficacy in drug delivery and ability to eliminate both bladder cancer cells and CSCs."

基金机构：Huxiang Young Talents Plan Project of Hunan Province [2019RS2015]; Natural Science Foundation of Hunan Province [2023JJ10092]; Wisdom Accumulation and Talent Cultivation Project of the Third xiangya hospital of Central South University [mnzl202030]; Beijing Bethune Charitable Foundation; [YX202204]

基金资助正文："This work was supported by Huxiang Young Talents Plan Project of Hunan Province (2019RS2015 to J.Y.L) , Natural Science Foundation of Hunan Province (2023JJ10092 to J.Y.L) , and Beijing Bethune Charitable Foundation (mnzl202030 to J.Y.L) , and The Wisdom Accumulation and Talent Cultivation Project of the Third xiangya hospital of Central South University (YX202204 to J.Y.L) ."