Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing

作者全名："Jiang, Min; Li, Silei; Ming, Piaoye; Guo, Ye; Yuan, Lingling; Jiang, Xueyu; Liu, Yunfei; Chen, Junliang; Xia, Delin; He, Yun; Tao, Gang"

作者地址："[Jiang, Min; Li, Silei; Ming, Piaoye; Guo, Ye; Yuan, Lingling; Jiang, Xueyu; Liu, Yunfei; Chen, Junliang; He, Yun; Tao, Gang] Southwest Med Univ, Affiliated Stomatol Hosp, Luzhou Key Lab Oral & Maxillofacial Reconstruct &, Luzhou 646000, Peoples R China; [Chen, Junliang; He, Yun] Southwest Med Univ, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, Luzhou 646000, Peoples R China; [Chen, Junliang; He, Yun; Tao, Gang] Southwest Med Univ, Sch Stomatol, Luzhou 646000, Peoples R China; [Xia, Delin] Chongqing Med Univ, Affiliated Hosp 2, Dept Plast & Maxillofacial Surg, Chongqing 400010, Peoples R China"

通信作者："He, Y; Tao, G (通讯作者)，Southwest Med Univ, Affiliated Stomatol Hosp, Luzhou Key Lab Oral & Maxillofacial Reconstruct &, Luzhou 646000, Peoples R China.; Xia, DL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Plast & Maxillofacial Surg, Chongqing 400010, Peoples R China."

来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000970879600001

JCR分区：Q1

影响因子：7.7

年份：2023

卷号：237

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Wound dressing; Antibacterial properties; Physically double cross -linking; Hybrid sponge; Wound healing

摘要："An ideal wound dressing should have excellent antimicrobial properties and provide a suitable microenviron-ment for regenerating damaged skin tissue. In this study, we utilized sericin to biosynthesize silver nanoparticles in situ and introduced curcumin to obtain Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent. The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge. The 3D structural networks were con-structed through electrostatic interactions between sodium alginate and chitosan and ionic interactions between sodium alginate and calcium ions. The prepared composite sponges have excellent hygroscopicity (contact angle 51.3 degrees +/- 5.6 degrees), moisture retention ability, porosity (67.32 % +/- 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). In addition, in vivo experiments have shown that the composite sponge promotes epithelial regen-eration and collagen deposition in wounds infected with S. aureus or P. aeruginosa. Tissue immunofluorescence staining analysis confirmed that the SC/Se-Ag/Cur complex sponge stimulated upregulated expression of CD31 to promote angiogenesis while downregulating TNF-alpha expression to reduce inflammation. These advantages make it an ideal candidate for infectious wound repair materials, providing an effective repair strategy for clinical skin trauma infections."

基金机构："Scientific Research Foundation of South-west Medical University [2020ZRZD011, 2021ZKMS018]; Project of Stomatological Institute of Southwest Medical University [2021XJYJS01]; Scientific Research Foundation of the Affiliated Sto-matological Hospital of Southwest Medical University [2020QY02, 2020QY06, 202007]"

基金资助正文："This work was funded by Scientific Research Foundation of South-west Medical University (2020ZRZD011, 2021ZKMS018) , Project of Stomatological Institute of Southwest Medical University (2021XJYJS01) , Scientific Research Foundation of the Affiliated Sto-matological Hospital of Southwest Medical University (2020QY02, 2020QY06, 202007) ."