Soluble Guanylate Cyclase Activators and Stimulators in Patients with Heart Failure

作者全名："Liang, Wei-Lin; Liang, Bo"

作者地址："[Liang, Wei-Lin] Guangyuan Hosp Chinese Med, Dept Cardiol, Guangyuan, Peoples R China; [Liang, Bo] Third Mil Med Univ, Army Med Univ, Chongqing Clin Res Ctr Kidney & Urol Dis, Xinqiao Hosp,Dept Nephrol,Key Lab Prevent & Treatm, Chongqing, Peoples R China"

通信作者："Liang, B (通讯作者)，Third Mil Med Univ, Army Med Univ, Chongqing Clin Res Ctr Kidney & Urol Dis, Xinqiao Hosp,Dept Nephrol,Key Lab Prevent & Treatm, Chongqing, Peoples R China."

来源：CURRENT CARDIOLOGY REPORTS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000971448200001

JCR分区：Q2

影响因子：3.1

年份：2023

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期号：　

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文献类型：Review; Early Access

关键词：Heart failure; Cardiac pharmacology; Soluble guanylate cyclase activators and stimulators; Cinaciguat; Riociguat; Vericiguat; Praliciguat

摘要："Purpose of ReviewThis review sought to summarize the current emerging soluble guanylate cyclase activators and stimulators in patients with heart failure, both heart failure with reduced and preserved ejection fraction, to provide a reference for soluble guanylate cyclase activators and stimulators discovery.Recent FindingsHeart failure is a common disease with considerable morbidity, hospitalization, and mortality Soluble guanylate cyclase is a key enzyme in the nitric oxide signaling pathway and has attracted rapidly growing interest as a therapeutic target in heart failure. Currently, several soluble guanylate cyclase agonists are in clinical development. Cinaciguat and praliciguat have shown no clear clinical benefit in patients with heart failure in clinical trials. Riociguat increased the 6-min walk distance, cardiac index, and stroke volume index as well as decreased N-terminal pro-B-type natriuretic peptide. Although these populations cover nearly every range of ejection fractions, these were not clinical trials directly in patients with heart failure but were designed in patients with pulmonary hypertension. Vericiguat is recommended in the latest American guideline for patients with heart failure with reduced ejection fraction; however, it gets mixed results in patients with heart failure with preserved ejection fraction.To date, only vericiguat reduces the composite of death from cardiovascular causes or first hospitalization for heart failure in patients with heart failure with reduced ejection fraction and riociguat might improve clinical symptoms and quality of life in patients with heart failure, both heart failure with reduced and preserved ejection fraction. We need more exploration about soluble guanylate cyclase activators and stimulators in patients with heart failure."

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