Research progress in the development of natural-product-based mucosal vaccine adjuvants

作者全名："Gao, Yingying; Guo, Ying"

作者地址："[Gao, Yingying; Guo, Ying] Chongqing Med Univ, Dept Clin Lab, Affiliated Banan Hosp, Chongqing, Peoples R China"

通信作者："Guo, Y (通讯作者)，Chongqing Med Univ, Dept Clin Lab, Affiliated Banan Hosp, Chongqing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000971616900001

JCR分区：Q1

影响因子：5.7

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：mucosal vaccines; adjuvants; polysaccharides; saponins; natural-product-based

摘要："Mucosal vaccines have great potential and advantages in preventing infection caused by multiple pathogens. In developing mucosal vaccines, the biggest challenge comes from finding safe and effective adjuvants and drug delivery systems. Great progress has been made in the generation of mucosal adjuvants using detoxified bacterial toxin derivatives, pathogen-related molecules, cytokines, and various vaccine delivery systems. However, many problems, relating to the safety and efficacy of mucosal vaccine adjuvants, remain. Certain natural substances can boost the immune response and thus could be used as adjuvants in vaccination. These natural-product-based immune adjuvants have certain advantages over conventional adjuvants, such as low toxicity, high stability, and low cost of production. In this review, we summarize the latest natural-product-based immune adjuvants, and discuss their properties and clinical applications."

基金机构：Chinese National Natural Science Foundation Project [31970078]

基金资助正文：This work was supported by Chinese National Natural Science Foundation Project (No. 31970078).