Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy

作者全名："Huang, Ju; Leng, Xiaojing; Jiang, Tao; Xu, Lihong; Zheng, Jun; Fang, Mingxiao; Wang, Jingxue; Wang, Zhigang; Zhang, Liang"

作者地址："[Huang, Ju; Leng, Xiaojing; Zheng, Jun; Fang, Mingxiao; Wang, Jingxue; Wang, Zhigang; Zhang, Liang] Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, State Key Lab Ultrasound Med & Engn, Chongqing 400010, Peoples R China; [Jiang, Tao] Southwest Med Univ, Affiliated Hosp, Dept Anesthesia, Luzhou 646000, Peoples R China; [Xu, Lihong] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China; [Zhang, Liang] Chongqing Med Univ, Affiliated Hosp 1, Dept Ultrasound, Chongqing 400042, Peoples R China; [Zhang, Liang] Chongqing Med Univ, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China; [Wang, Zhigang] Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, State Key Lab Ultrasound Med & Engn,Chongqing Key, Chongqing, Peoples R China"

通信作者："Wang, ZG; Zhang, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, State Key Lab Ultrasound Med & Engn, Chongqing 400010, Peoples R China.; Zhang, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China.; Wang, ZG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, State Key Lab Ultrasound Med & Engn,Chongqing Key, Chongqing, Peoples R China."

来源：MATERIALS TODAY BIO

ESI学科分类：　

WOS号：WOS:000972703100001

JCR分区：Q1

影响因子：8.7

年份：2023

卷号：19

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Hypoxia; Tumor immunosuppressive microenvironment; Photothermal-immunotherapy; Nanomedicine

摘要："Immunotherapy shows great promise on treating tumors. However, insufficient antigen exposure and immuno-suppressive tumor microenvironment (TME) caused by hypoxia impose a serial of constraints on the therapeutic efficacy. In this study, we developed an oxygen-carrying nanoplatform loaded with perfluorooctyl bromide (PFOB, a second-generation of perfluorocarbon-based blood substitute), IR780 (a photosensitizer) and imiquimod (R837, an immune adjuvant) to reprogram immunosuppressive TME and reinforce photothermal-immunotherapy. The obtained oxygen-carrying nanoplatforms (abbreviated as IR-R@LIP/PFOB) show highly efficient oxygen release behavior and excellent hyperthermia performance upon laser irradiation, thus achieving the attenuation of the inherent tumor hypoxia and the exposure of tumor associated antigens in situ, and transforming the immunosuppressive TME to an immunosupportive one. We found that the photothermal therapy of IR-R@LIP/ PFOB together with anti-programmed cell death protein-1 (anti-PD-1) would elicit a robust antitumor immu-nity by increasing the tumor-infiltrating frequencies of cytotoxic CD8 thorn T cells and tumoricidal M1-phenotype macrophages, while reducing immunosuppressive M2-phenotype macrophages and regulatory T cells (Tregs). This study presents these oxygen-carrying IR-R@LIP/PFOB nanoplatforms are potent in removing some negative impacts of immunosuppressive TME caused by hypoxia, and suppressing tumor growth by initiating antitumor immune responses, especially in combination with anti-PD-1 immunotherapy."

基金机构："National Natural Science Foundation of China [82172092, 82202175]; Key Project of Application Devel-opment Plan of Chongqing [cstc2019jscx-dxwtBX0004]; Nat-ural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0093]; China Postdoctoral Science Foundation [2021TQ0394, 2021M00637]; Chongqing Post-doctoral Program for Innovative Talents"

基金资助正文："Acknowledgements This work was supported by the National Natural Science Foundation of China (82172092 and 82202175) , Key Project of Application Devel-opment Plan of Chongqing (cstc2019jscx-dxwtBX0004) , and the Nat-ural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0093) . The authors also appreciate the China Postdoctoral Science Foundation (Grant No. 2021TQ0394, 2021M00637) , and the Chongqing Post-doctoral Program for Innovative Talents."