Neurodevelopmental outcomes of neonatal posthemorrhagic hydrocephalus and psychological effects on the parents

作者全名："Wu, Yuxin; Liang, Ping; Li, Lusheng; Zhou, Yudong; Wang, Difei; Zhai, Xuan"

作者地址："[Wu, Yuxin; Liang, Ping; Li, Lusheng; Zhou, Yudong; Wang, Difei; Zhai, Xuan] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,China In, 136,Zhongshan 2nd Rd, Chongqing 400010, Peoples R China"

通信作者："Zhai, X (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,China In, 136,Zhongshan 2nd Rd, Chongqing 400010, Peoples R China."

来源：CHILDS NERVOUS SYSTEM

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000972850300001

JCR分区：Q3

影响因子：1.3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Intraventricular haemorrhage; Posthemorrhagic hydrocephalus; Outcomes; Anxiety; Depression

摘要："BackgroundNeonatal posthemorrhagic hydrocephalus remains a common complication in preterm infants, with high rates of mortality and morbidity, placing parents at high risk of anxiety and depression. We sought to investigate the neurodevelopmental outcomes of infants with posthemorrhagic hydrocephalus who underwent surgery and the psychological effect on their parents.MethodsWe retrospectively analysed all infants with posthemorrhagic hydrocephalus born between 2014 and 2020 in the Children's Hospital of Chongqing Medical University, China. The neurodevelopmental outcomes of 28 patients were evaluated by the Pediatric Stroke Outcome Measure score, and the psychological states of the parents of survivors were assessed by the Hospital Anxiety and Depression Scale.ResultsThe families of the 28 patients were followed up for a median duration of 3 years; 6 (21.4%) patients died within 6 months after discharge, 12 (42.9%) patients had moderate to severe dysfunction, and only 10 (35.7%) patients had good outcomes. Regarding the 22 parents of the survivors, 5 (22.7%) and 4 (18.2%) had borderline anxiety and depression symptoms, respectively. Two (9.1%) caregivers had exact anxiety and depression symptoms. Leukomalacia after intraventricular haemorrhage was associated with adverse neurological outcomes. The infants' histories of epileptic seizures during the neonatal period were associated with the anxiety of their parents.ConclusionThe overall outcome of posthemorrhagic hydrocephalus patients is unsatisfactory, and children with leukomalacia after haemorrhage tend to have poor outcomes. A history of epileptic seizures during the course of the disease may exacerbate the anxiety of the caregivers."

基金机构：National Natural Science Foundation [81971217]; Scientific Research Project of the National Clinical Research Center for Child Health and Disorders [YBXM-2019-17]

基金资助正文：The present study was supported by the National Natural Science Foundation (No. 81971217) and the Scientific Research Project of the National Clinical Research Center for Child Health and Disorders (YBXM-2019-17).