Focused ultrasound ablation surgery for multiple breast fibroadenomas: pathological and follow-up results

作者全名："Yue, Xuewen; Li, Zi; Yin, Heng; Xiao, Yao; Yang, Lei; Chen, Maoshan; Huang, Haoran; Yang, Hongwei; Wang, Zhibiao; Zhang, Cai"

作者地址："[Yue, Xuewen; Li, Zi; Xiao, Yao; Huang, Haoran; Wang, Zhibiao; Zhang, Cai] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Yue, Xuewen; Li, Zi; Xiao, Yao; Huang, Haoran; Wang, Zhibiao; Zhang, Cai] Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing, Peoples R China; [Yin, Heng; Yang, Lei; Chen, Maoshan; Yang, Hongwei] Suining Cent Hosp, Dept Breast Surg, Suining, Peoples R China; [Huang, Haoran; Wang, Zhibiao; Zhang, Cai] Chongqing Haifu Hosp, Chongqing, Peoples R China; [Huang, Haoran; Zhang, Cai] Natl Engn Res Ctr Ultrasound Med, Chongqing, Peoples R China"

通信作者："Wang, ZB; Zhang, C (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China.; Wang, ZB; Zhang, C (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing, Peoples R China.; Wang, ZB; Zhang, C (通讯作者)，Chongqing Haifu Hosp, Chongqing, Peoples R China.; Zhang, C (通讯作者)，Natl Engn Res Ctr Ultrasound Med, Chongqing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000972920600001

JCR分区：Q2

影响因子：3

年份：2023

卷号：40

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Multiple fibroadenomas; focused ultrasound ablation surgery; histopathology; coagulative necrosis; shrinkage rate

摘要："Objective To investigate the histopathological findings and follow-up outcome of focused ultrasound ablation surgery (FUAS) treatment of multiple fibroadenomas (FA). Methods A total of 20 patients with 101 multiple FAs were enrolled. After one session FUAS ablation, 21 lesions (>= 15.0 mm) were surgically removed within one week for histopathological analysis, including 2, 3, 5-triphenyltetrazolium chloride (TTC) staining, H&E staining, nicotinamide adenine dinucleotide (NADH) -flavretin enzyme staining, Transmission electron microscope (TEM) and scanning electron microscope (SEM). The remaining 80 lesions were followed up at 3, 6 and 12 months after treatment. Results All ablation procedures were performed successfully. Pathologic findings showed that irreversible damage of FA was confirmed. TTC, H&E and NADH staining and TEM/SEM demonstrated tumor cell death and tumor structural destruction at the gross, cellular, and subcellular levels, respectively. The median shrinkage rate at 12 months post-FUAS was 66.4 (43.6, 89.5) %. Conclusion Histopathological analysis for FAs after FUAS treatment proved that FUAS could effectively induce irreversible coagulative necrosis of FA, and the tumor volume would gradually shrink in follow-up. FUAS was safe and effective to treat multiple FAs with good cosmesis."

基金机构：Foundation of State Key Laboratory of Ultrasound in Medicine and Engineering [2021KFKT016]

基金资助正文：This work was partially supported by the Foundation of State Key Laboratory of Ultrasound in Medicine and Engineering [Grant No. 2021KFKT016].