Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications
作者全名："Yin, Yuanyuan; Yang, Sihan; Ai, Dongqing; Qin, Han; Sun, Yu; Xia, Xuyun; Xu, Xiaohui; Ji, Wei; Song, Jinlin"
作者地址："[Yin, Yuanyuan; Yang, Sihan; Ai, Dongqing; Qin, Han; Sun, Yu; Xu, Xiaohui; Song, Jinlin] Chongqing Med Univ, Coll Stomatol, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China; [Xia, Xuyun] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China; [Ji, Wei] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China"
通信作者："Xu, XH; Song, JL (通讯作者)，Chongqing Med Univ, Coll Stomatol, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China.; Ji, W (通讯作者)，Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China."
来源：ADVANCED FUNCTIONAL MATERIALS
ESI学科分类：MATERIALS SCIENCE
WOS号：WOS:000975657800001
JCR分区：Q1
影响因子：18.5
年份：2023
卷号：
期号：
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结束页：
文献类型：Review; Early Access
关键词：bioactive agents; biomaterials; drug delivery; functional hydrogels; periodontal applications
摘要："Periodontitis is a biofilm-induced, host-mediated inflammatory disease that results in periodontal tissue destruction. The design of functional biomaterials based on disease pathophysiology is essential for enhancing their therapeutic effects in periodontitis treatment. As promising localized drug delivery systems and tissue engineering scaffolds, hydrogels have gained significant interest for controlled and sustained release of bioactive agents in periodontal applications. The rational design of bioactive hydrogels can facilitate bacterial control and modulate destructive host inflammation, thereby preventing the progression of periodontitis. In this review, the pathophysiological mechanisms underlying periodontitis as fundamental principles for the design of functional hydrogel systems are first introduced. In the following part, an overview is systematically provided of the types and functions of the bioactive hydrogel systems loaded with anti-bacterial and anti-inflammatory agents for periodontal delivery. Finally, the remaining challenges and future perspectives of hydrogel delivery systems for periodontal applications are proposed. It is believed that this review will inspire the rational design and development of innovative functional hydrogel biomaterials toward periodontal therapy."
基金机构："National Key R&D of Program of China [2022YFC2504200]; National Natural Science Foundation of China [U22A20314, 52103148, 81771082, 82101014, cx2021055]; China Postdoctoral Science Foundation [2021M700628]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-BHX0632, cstc2021jcyj-bsh0005]"
基金资助正文："Acknowledgements This work was supported by the National Key R&D of Program of China (Grant No. 2022YFC2504200), National Natural Science Foundation of China (Grant No. U22A20314; 52103148; 81771082; 82101014), Returning Overseas Scholar Innovation Program (cx2021055), China Postdoctoral Science Foundation (Grant No. 2021M700628), and Natural Science Foundation of Chongqing (Grant No. CSTB2022NSCQ-BHX0632; cstc2021jcyj-bsh0005)."
