Remote Ischemic Conditioning Relieves Necrotizing Enterocolitis Through Regulation of Redox and Inflammation

作者全名："Zhang, Yunfei; Liu, Qianyang; Gao, Kai; Tian, Bing; Zhu, Hai; Liu, Jian; Hu, Yuhui; Ye, Cuilian; Guo, Chunbao"

作者地址："[Zhang, Yunfei; Liu, Qianyang; Gao, Kai; Tian, Bing; Zhu, Hai; Ye, Cuilian; Guo, Chunbao] Chongqing Med Univ, Women & Childrens Hosp, Dept Pediat, Chongqing, Peoples R China; [Zhang, Yunfei; Liu, Qianyang; Gao, Kai; Tian, Bing; Zhu, Hai; Ye, Cuilian; Guo, Chunbao] Chongqing Hlth Ctr Women & Children, Dept Pediat, Chongqing, Peoples R China; [Zhang, Yunfei; Liu, Jian; Hu, Yuhui] Renshou Peoples Hosp, Dept Gastrointestinal Surg, Meishan, Peoples R China; [Ye, Cuilian] Chongqing Univ Technol, Sch Pharm & Bioengn, Chongqing, Peoples R China; [Guo, Chunbao] Chongqing Med Univ, Women & Childrens Hosp, Dept Pediat, 120 Longshan Rd, Chongqing 400014, Peoples R China"

通信作者："Guo, CB (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Pediat, 120 Longshan Rd, Chongqing 400014, Peoples R China."

来源：JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000975740100001

JCR分区：Q4

影响因子：1.9

年份：2023

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期号：　

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文献类型：Article; Early Access

关键词：remote ischemic conditioning; necrotizing enterocolitis; redox; inflammation; glutaredoxin-1; PI3K

摘要："In neonates, necrotizing enterocolitis (NEC) is a serious condition involving oxidative stress and inflammation. Remote ischemic conditioning (RIC) is a potentially useful technique to protect distant organs from the damage induced by ischemia. RIC has been verified as effective to protect against NEC; however, its mechanism is unclear. This study aimed to assess the mechanism and efficacy of RIC to treat experimental NEC in mice. Between postnatal day (P) 5 and P9, we induced NEC in C57BL/6 mice and Grx1(-/-) mice. Intermittent occlusion of the blood flow to the right hind limb for 4 cycles of 5 min ischemia followed by 5 min reperfusion during NEC induction on P6 and P8 was used to apply RIC. We sacrificed the mice on p9 and evaluated oxidative stress, inflammatory cytokines, proliferation, apoptosis, and PI3K/Akt/mTOR signal pathway in mice ileal tissue. RIC decreased intestinal injury and prolonged survival in NEC pups. RIC significantly inhibited inflammatory, attenuated oxidative stress, reduced apoptosis, promoted proliferation, and activated PI3K/Akt/mTOR in vivo. RIC activates the PI3K/Akt/mTOR signaling pathway to control oxidative stress and inflammation. RIC might provide a new therapeutic strategy for NEC."

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