"Photoinduced, Silver(I)-Mediated Synthesis of Ester-Substituted Fused Quinazolinones via Cascade Alkoxycarbonylation/Cyclization of Heterocycles Bearing Unactivated Alkenes"

作者全名："Xiao, Hui-Xin; Li, Pan-Pan; Pan, Bin; Liang, Wu; Du, Fei; Yu, Yu"

作者地址："[Xiao, Hui-Xin; Li, Pan-Pan; Liang, Wu; Du, Fei; Yu, Yu] Chongqing Med Univ, Coll Pharm, Dept Med Chem, Chongqing 400016, Peoples R China; [Pan, Bin] Third Mil Med Univ, Coll Pharm, Chongqing 400038, Peoples R China"

通信作者："Du, F; Yu, Y (通讯作者)，Chongqing Med Univ, Coll Pharm, Dept Med Chem, Chongqing 400016, Peoples R China."

来源：JOURNAL OF ORGANIC CHEMISTRY

ESI学科分类：CHEMISTRY

WOS号：WOS:000975903600001

JCR分区：Q1

影响因子：3.3

年份：2023

卷号：88

期号：9

开始页：5861

结束页：5874

文献类型：Article

关键词：　

摘要："A new cascade alkoxycarbonylation/cyclization reaction of heterocycle-bearing unactivated alkenes is disclosed. The transformation is mediated by silver carbonate under photoirradiation. This method provides efficient access to pharmaceutically valuable molecules and natural product analogues containing quinazolinone-fused esters. Furthermore, this protocol is compatible with a variety of quinazolinone-bearing unactivated alkenes and alkyloxalyl chlorides that are readily prepared from abundant alcohols and oxalyl chlorides."

基金机构：Natural Science Foundation of Chongqing; Chongqing Medical University Start-Up Fund [KJQN202100415]; Science and Technology Research Program of Chongqing Municipal Education Commission [cstc2021jcyj-msxmX0201]; [R13008]

基金资助正文："The authors are grateful for the financial support from the Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0201), the Chongqing Medical University Start-Up Fund (R13008), and the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJQN202100415)."