Functional connectivity changes are correlated with sleep improvement in chronic insomnia patients after rTMS treatment
作者全名："Zhu, Lin; Dang, Ge; Wu, Wei; Zhou, Junhong; Shi, Xue; Su, Xiaolin; Ren, Huixia; Pei, Zian; Lan, Xiaoyong; Lian, Chongyuan; Xie, Peng; Guo, Yi"
作者地址："[Zhu, Lin; Dang, Ge; Shi, Xue; Su, Xiaolin; Guo, Yi] Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China; [Wu, Wei] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA USA; [Zhou, Junhong] Harvard Med Sch, Hinda & Arthur Marcus Inst Aging Res, Hebrew Seniorlife, Boston, MA USA; [Ren, Huixia] Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Geriatr,Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China; [Pei, Zian; Lan, Xiaoyong; Lian, Chongyuan; Guo, Yi] Shenzhen Bay Lab, Shenzhen, Guangdong, Peoples R China; [Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, NHC Key Lab Diag & Treatment Brain Funct Dis, Chongqing, Peoples R China"
通信作者："Guo, Y (通讯作者)，Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China.; Guo, Y (通讯作者)，Shenzhen Bay Lab, Shenzhen, Guangdong, Peoples R China."
来源：FRONTIERS IN NEUROSCIENCE
ESI学科分类：NEUROSCIENCE & BEHAVIOR
WOS号：WOS:000976224100001
JCR分区：Q2
影响因子：3.2
年份：2023
卷号：17
期号：
开始页：
结束页：
文献类型：Article
关键词：chronic insomnia disorder; rTMS; EEG; functional connectivity; DLPFC
摘要："BackgroundRepetitive transcranial magnetic stimulation (rTMS) has been increasingly used as a treatment modality for chronic insomnia disorder (CID). However, our understanding of the mechanisms underlying the efficacy of rTMS is limited. ObjectiveThis study aimed to investigate rTMS-induced alterations in resting-state functional connectivity and to find potential connectivity biomarkers for predicting and tracking clinical outcomes after rTMS. MethodsThirty-seven patients with CID received a 10-session low frequency rTMS treatment applied to the right dorsolateral prefrontal cortex. Before and after treatment, the patients underwent resting-state electroencephalography recordings and a sleep quality assessment using the Pittsburgh Sleep Quality Index (PSQI). ResultsAfter treatment, rTMS significantly increased the connectivity of 34 connectomes in the lower alpha frequency band (8-10 Hz). Additionally, alterations in functional connectivity between the left insula and the left inferior eye junction, as well as between the left insula and medial prefrontal cortex, were associated with a decrease in PSQI score. Further, the correlation between the functional connectivity and PSQI persisted 1 month after the completion of rTMS as evidenced by subsequent electroencephalography (EEG) recordings and the PSQI assessment. ConclusionBased on these results, we established a link between alterations in functional connectivity and clinical outcomes of rTMS, which suggested that EEG-derived functional connectivity changes were associated with clinical improvement of rTMS in treating CID. These findings provide preliminary evidence that rTMS may improve insomnia symptoms by modifying functional connectivity, which can be used to inform prospective clinical trials and potentially for treatment optimization."
基金机构：Natural Science Foundation of Guangdong Province [2021A1515010983]; Sanming Project of Medicine in Shenzhen [SZSM202111009]; Shenzhen Science and Technology Innovation Program [KCXFZ20201221173400001]; Shenzhen Key Medical Discipline Construction Fund [SZXK005]
基金资助正文："Funding This study was supported by the Natural Science Foundation of Guangdong Province (grant number 2021A1515010983), the Sanming Project of Medicine in Shenzhen (grant number SZSM202111009), the Shenzhen Science and Technology Innovation Program (grant number KCXFZ20201221173400001), and Shenzhen Key Medical Discipline Construction Fund (grant number SZXK005)."
