Acalculous cholecystitis is a common extrahepatic manifestation of hepatitis E and suggests a more serious condition

作者全名："Cao, Xuemei; Jiang, Wei; Shi, Lingfeng; Wang, Yanping; Chen, Jie; Huang, Wenxiang; Zhang, Shujun"

作者地址："[Cao, Xuemei; Jiang, Wei; Shi, Lingfeng; Chen, Jie; Huang, Wenxiang; Zhang, Shujun] Chongqing Med Univ, Dept Infect Dis, Chongqing Key Lab Infect Dis & Parasit Dis, Affiliated Hosp 1, 1 Youyi Rd,Yuzhong Dist, Chongqing 400016, Peoples R China; [Shi, Lingfeng] Chongqing Med Univ, Youyang Hosp, Dept Infect Dis, Branch Affiliated Hosp 1, Chongqing, Peoples R China; [Wang, Yanping] Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Zhang, SJ (通讯作者)，Chongqing Med Univ, Dept Infect Dis, Chongqing Key Lab Infect Dis & Parasit Dis, Affiliated Hosp 1, 1 Youyi Rd,Yuzhong Dist, Chongqing 400016, Peoples R China."

来源：VIROLOGY JOURNAL

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000976371500001

JCR分区：Q2

影响因子：4

年份：2023

卷号：20

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Hepatitis E; Acalculous cholecystitis; Spontaneous peritonitis; Hospital stay

摘要："BackgroundThis study aimed to understand the incidence and clinical significance of acalculous cholecystitis in patients with acute hepatitis E (HE).Patients and methodsA single center enrolled 114 patients with acute HE. All patients underwent imaging of the gallbladder, and patients with gallstones and cholecystectomy were excluded.ResultsAcalculous cholecystitis was found in 66 patients (57.89%) with acute HE. The incidence in males was 63.95%, which was significantly higher than in females (39.29%) (P = 0.022). The mean length of hospital stay and the incidence of spontaneous peritonitis in patients with cholecystitis (20.12 +/- 9.43 days and 9.09%, respectively) were significantly higher than those in patients without cholecystitis (12.98 +/- 7.26 days and 0%, respectively) (P < 0.001 and P = 0.032). Albumin, total bile acid, bilirubin, cholinesterase, and prothrombin activity in patients with cholecystitis were significantly inferior to those in patients without cholecystitis (P < 0.001, P < 0.001, P < 0.001, P < 0.001 and P = 0.003, respectively). After correction by multivariate analysis, albumin and total bile acid were found to be closely related to acalculous cholecystitis in HE.ConclusionAcalculous cholecystitis is very common in patients with acute HE, and may serve as a predictor of increased peritonitis, synthetic decompensation, and longer hospital stay."

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