Self-Assembling Peptide SCIBIOIII Hydrogel for Three-Dimensional Cell Culture That Promotes Wound Healing in Diabetic Mice

作者全名："He, Lu; Lan, Shijian; Cheng, Qingfeng; Luo, Zhongli; Lin, Xuemei"

作者地址："[He, Lu; Lin, Xuemei] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China; [He, Lu] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Key Lab Translat Med Major Metab Dis, Chongqing 400016, Peoples R China; [Lan, Shijian; Luo, Zhongli] Chongqing Med Univ, Coll Basic Med Sci, Mol Med & Canc Res Ctr, Chongqing 400016, Peoples R China; [Cheng, Qingfeng] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing 400016, Peoples R China"

通信作者："Lin, XM (通讯作者)，Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China."

来源：GELS

ESI学科分类：　

WOS号：WOS:000977693900001

JCR分区：Q1

影响因子：5

年份：2023

卷号：9

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：self-assembling peptide; SCIBIOIII; cellular 3D culture; diabetic wound

摘要："An important clinical challenge is improving the healing rate of diabetic chronic wounds, and developing new approaches that can promote chronic wound healing is essential. A new biomaterial that has demonstrated great potential for tissue regeneration and repair is self-assembling peptides (SAPs); however, they have been less studied for the treatment of diabetic wounds. Here, we explored the role of an SAP, SCIBIOIII, with a special nanofibrous structure mimicking the natural extracellular matrix for chronic diabetic wound repair. The results showed that the SCIBIOIII hydrogel in vitro has good biocompatibility and can create a three-dimensional (3D) culture microenvironment for the continuous growth of skin cells in a spherical state. The SCIBIOIII hydrogel in diabetic mice (in vivo) significantly improved wound closure, collagen deposition, and tissue remodeling and enhanced chronic wound angiogenesis. Thus, the SCIBIOIII hydrogel is a promising advanced biomaterial for 3D cell culture and diabetic wound tissue repair."

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