Effects of Propofol on Cortical Electroencephalograms in the Operation of Glioma-Related Epilepsy

作者全名："Li, Xin; Wei, Yu; Xie, Yanfeng; Shi, Quanhong; Zhan, Yan; Dan, Wei; Jiang, Li"

作者地址："[Li, Xin; Wei, Yu; Xie, Yanfeng; Shi, Quanhong; Zhan, Yan; Dan, Wei; Jiang, Li] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing 400016, Peoples R China"

通信作者："Dan, W; Jiang, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing 400016, Peoples R China."

来源：BRAIN SCIENCES

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000977733500001

JCR分区：Q3

影响因子：2.7

年份：2023

卷号：13

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：propofol; epilepsy; cortical electroencephalogram; glioma-related epilepsy; epilepsy surgery

摘要："Background: A cortical electroencephalogram (ECoG) is often used for the intraoperative monitoring of epilepsy surgery, and propofol is an important intravenous anesthetic, but its effect on EEGs is unclear. Objectives: To further clarify the effect of propofol on cortical ECoGs during glioma-related epilepsy surgery and to clarify the possible clinical value. Methods: A total of 306 patients with glioma were included in the study. Two hundred thirty-nine with glioma-related epilepsy were included in the epilepsy group, and 67 without glioma-related epilepsy were included in the control group. All patients experienced continuous, real-time ECoG monitoring and long-term follow-up after surgery. Results: After injection of low-dose propofol, the rate of activated ECoGs in the epilepsy group (74%) was significantly higher than in the control group (9%). Furthermore, compared with patients in the untreated group, patients in the treated group had lower rates of early and long-term postoperative seizure frequencies and fewer interictal epileptiform discharges (IEDs). Conclusions: Low-dose infusion of propofol can specifically activate ECoGs in epilepsy patients. Therefore, activated ECoGs might provide an accurate and reliable method for identifying potential epileptic zones during glioma-related epilepsy surgery, resulting in better early and long-term prognoses after epilepsy surgery."

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