"Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications"

作者全名："Xu, Yamei; Hu, Qiyuan; Wei, Zongyun; Ou, Yi; Cao, Youde; Zhou, Hang; Wang, Mengna; Yu, Kexiao; Liang, Bing"

作者地址："[Xu, Yamei; Hu, Qiyuan; Wei, Zongyun; Ou, Yi; Cao, Youde; Zhou, Hang; Wang, Mengna; Liang, Bing] Chongqing Med Univ, Coll Basic Med, Dept Pathol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Xu, Yamei; Hu, Qiyuan; Wei, Zongyun; Ou, Yi; Cao, Youde; Wang, Mengna; Liang, Bing] Chongqing Med Univ, Mol Med Diagnost & Testing Ctr, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Cao, Youde; Liang, Bing] Chongqing Med Univ, Dept Pathol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400042, Peoples R China; [Yu, Kexiao] Chongqing Tradit Chinese Med Hosp, Dept Orthoped, 6 Panxi Seventh Branch Rd, Chongqing 400021, Peoples R China; [Yu, Kexiao] Chongqing Med Univ, Inst Ultrasound Imaging, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Liang, B (通讯作者)，Chongqing Med Univ, Coll Basic Med, Dept Pathol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.; Liang, B (通讯作者)，Chongqing Med Univ, Mol Med Diagnost & Testing Ctr, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.; Liang, B (通讯作者)，Chongqing Med Univ, Dept Pathol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400042, Peoples R China.; Yu, KX (通讯作者)，Chongqing Tradit Chinese Med Hosp, Dept Orthoped, 6 Panxi Seventh Branch Rd, Chongqing 400021, Peoples R China.; Yu, KX (通讯作者)，Chongqing Med Univ, Inst Ultrasound Imaging, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：BIOMATERIALS RESEARCH

ESI学科分类：　

WOS号：WOS:000978199800001

JCR分区：Q1

影响因子：8.1

年份：2023

卷号：27

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Diabetic ulcers; Hydrogels; Wound healing; Polymers; Mechanism

摘要："Diabetic ulcers (DUs) are one of the most serious complications of diabetes mellitus. The application of a functional dressing is a crucial step in DU treatment and is associated with the patient's recovery and prognosis. However, traditional dressings with a simple structure and a single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer dressings and hydrogels to solve the therapeutic bottleneck of DU treatment. Hydrogels are a class of gels with a three-dimensional network structure that have good moisturizing properties and permeability and promote autolytic debridement and material exchange. Moreover, hydrogels mimic the natural environment of the extracellular matrix, providing suitable surroundings for cell proliferation. Thus, hydrogels with different mechanical strengths and biological properties have been extensively explored as DU dressing platforms. In this review, we define different types of hydrogels and elaborate the mechanisms by which they repair DUs. Moreover, we summarize the pathological process of DUs and review various additives used for their treatment. Finally, we examine the limitations and obstacles that exist in the development of the clinically relevant applications of these appealing technologies."

基金机构： [YZ24NEEORV]; [PT24OKYFIX]; [XA24PB1Z97]

基金资助正文："AcknowledgementsAll completed graphics are created with BioRender.com (Agreement numbers: YZ24NEEORV, PT24OKYFIX and XA24PB1Z97)"