Ethyl Vanillin Rapid Crystallization from Carboxymethyl Chitosan Ion-Switchable Hydrogels

作者全名："Huang, Chenghong; Tang, Hong; Huang, Xiaorong; Chen, Hongjie; Yang, Kang; Yin, Qi; Zhang, Lin; Li, Xia; Mou, Xue; Chen, Shuangkou; Zhang, Yuchan; Hu, Yan"

作者地址："[Huang, Chenghong; Tang, Hong; Huang, Xiaorong; Chen, Hongjie; Yang, Kang; Yin, Qi; Zhang, Lin; Li, Xia; Mou, Xue; Chen, Shuangkou] Chongqing Univ Sci & Technol, Sch Chem & Chem Engn, Chongqing 401331, Peoples R China; [Zhang, Yuchan] Chongqing Med Univ, Inst Life Sci, Lab Teaching & Management Ctr, Chongqing 400016, Peoples R China; [Zhang, Yuchan] Chongqing Med Univ, Lab Tissue & Cell Biol, Lab Teaching & Management Ctr, Chongqing 400016, Peoples R China; [Hu, Yan] Chongqing TB Control Inst, TB Reference Lab, Chongqing 400050, Peoples R China"

通信作者："Huang, CH (通讯作者)，Chongqing Univ Sci & Technol, Sch Chem & Chem Engn, Chongqing 401331, Peoples R China."

来源：GELS

ESI学科分类：　

WOS号：WOS:000979338400001

JCR分区：Q1

影响因子：5

年份：2023

卷号：9

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：EVA; CMCS; crystallization; nanoconfinement

摘要："Polymer gels are usually used for crystal growth as the recovered crystals have better properties. Fast crystallization under nanoscale confinement holds great benefits, especially in polymer microgels as its tunable microstructures. This study demonstrated that ethyl vanillin can be quickly crystallized from carboxymethyl chitosan/ethyl vanillin co-mixture gels via classical swift cooling method and supersaturation. It found that EVA appeared with bulk filament crystals accelerated by a large quantity of nanoconfinement microregions resulted from space-formatted hydrogen network between EVA and CMCS when their concentration exceeds 1:1.4 and may occasionally arise when the concentration less than 1:0.8. It was observed that EVA crystal growth has two models involving hang-wall growth at the air-liquid interface at the contact line, as well as extrude-bubble growth at any sites on the liquid surface. Further investigations found that EVA crystals can be recovered from as-prepared ion-switchable CMCS gels by 0.1 M hydrochloric acid or acetic acid without defects. Consequently, the proposed method may offer an available scheme for a large-scale preparation of API analogs."

基金机构："NSF of Chongqing [CSTB2022TFII-OFX0022, CSTB2023NSCQ-MSX3562]; Open Fund of Chongqing Key Laboratory of Industrial Fermentation Microorganism [GYFJWSW-201905]; Graduate Innovation Fund of CQUST [CQUST2022107, CQUST2022110, YKJCX2220508]"

基金资助正文："This research was funded by NSF of Chongqing grant number (CSTB2022TFII-OFX0022 and CSTB2023NSCQ-MSX3562), Open Fund of Chongqing Key Laboratory of Industrial Fermentation Microorganism (GYFJWSW-201905) and Graduate Innovation Fund of CQUST (CQUST2022107, CQUST2022110 and YKJCX2220508)."