Hemoglobin-Decorated Boron-Carbon Nanosheets with Catalytic Ability and Near-Infrared II Light Response for Tumor Photothermal- Chemodynamic Therapy

作者全名："Chen, Chunmei; Zhang, Wei; Ouyang, Yi; Tan, Yixin; Zhao, Sheng; Chen, Yan; He, Liang; Lu, Shi-Yu; Ran, Haitao; Liu, Hui"

作者地址："[Chen, Chunmei; Ouyang, Yi; Tan, Yixin; Zhao, Sheng; Chen, Yan; He, Liang; Liu, Hui] Southwest Univ, Sch Mat & Energy, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, Chongqing 400715, Peoples R China; [Zhang, Wei; Ran, Haitao] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China; [Lu, Shi-Yu] Chongqing Univ Sci & Technol, Coll Met & Mat Engn, Chongqing 401331, Peoples R China"

通信作者："Liu, H (通讯作者)，Southwest Univ, Sch Mat & Energy, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, Chongqing 400715, Peoples R China.; Ran, HT (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China.; Lu, SY (通讯作者)，Chongqing Univ Sci & Technol, Coll Met & Mat Engn, Chongqing 401331, Peoples R China."

来源：ACS APPLIED NANO MATERIALS

ESI学科分类：　

WOS号：WOS:000979513500001

JCR分区：Q2

影响因子：5.3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：boron-carbon nanosheets; hemoglobin; photothermal therapy; chemodynamic therapy; tumor

摘要："Carbon-based nanomaterials are a kind of attractive photothermal agents (PTAs) for tumor photothermal therapy (PTT). However, their inherent fluorescent emission always compromises the photothermal conversion efficiency and is a huge obstruction that needs to be solved. Herein, a kind of hemoglobin (Hb)-decorated boron-carbon nanosheets (BC NSs) was designed and developed with catalytic ability and near-infrared II light-responsive performance for photoacoustic (PA) imaging guided synergistic tumor PTT/chemodynamic therapy (CDT). BC NSs were synthesized from biomass gelatin, coated with a polydopamine (PDA) layer, and decorated with Fenton agent Hb. The formed BC-PDA-Hb (BCPH) NSs had no fluorescent emission, high photothermal conversion performance (47.8% under 1064 nm laser irradiation), and excellent PA imaging capability. The Fe2+ carried in Hb can react with intratumoral overexpressed H2O2 to generate toxic hydroxyl radicals. In vitro and in vivo data revealed that BCPH NSs can achieve effective tumor elimination through synergistic PTT/CDT without detectable adverse effects on normal tissues. This work offers an effective strategy to develop carbon-based nanomedicines owning promoted photothermal performance and high biocompatibility for tumor theranostic applications."

基金机构：Young Elite Scientists Sponsorship Program by CAST [2021QNRC001]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0557]; Talent Introduction of Chongqing University of Science and Technology [ckrc2021050]

基金资助正文："? ACKNOWLEDGMENTS This research was funded by the Young Elite Scientists Sponsorship Program by CAST (2021QNRC001) , Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0557) , and Talent Introduction of Chongqing University of Science and Technology (No. ckrc2021050) ."