Novel tumor necrosis factor-related long non-coding RNAs signature for risk stratification and prognosis in glioblastoma

作者全名："Long, Shengrong; Wu, Bingbing; Yang, Liu; Wang, Lesheng; Wang, Bo; Yan, Yu; Jiang, Jiazhi; Yang, Bin; Zhou, Qiangqiang; Shi, Min; Liang, Wu; Wei, Wei; Li, Xiang"

作者地址："[Long, Shengrong; Wang, Lesheng; Wang, Bo; Yan, Yu; Jiang, Jiazhi; Yang, Bin; Zhou, Qiangqiang; Shi, Min; Wei, Wei; Li, Xiang] Wuhan Univ, Zhongnan Hosp, Dept Neurosurg, Wuhan, Peoples R China; [Long, Shengrong; Wang, Lesheng; Wang, Bo; Yan, Yu; Jiang, Jiazhi; Yang, Bin; Zhou, Qiangqiang; Shi, Min; Wei, Wei; Li, Xiang] Wuhan Univ, Zhongnan Hosp, Brain Res Ctr, Wuhan, Peoples R China; [Wu, Bingbing] Chongqing Med Univ, Yongchuan Hosp, Dept Neurosurg, Chongqing, Peoples R China; [Yang, Liu] Cent Theater Gen Hosp Chinese Peoples Liberat Army, Dept Neurosurg, Wuhan, Peoples R China; [Liang, Wu] Hubei Univ Nationalities, Affiliated Minda Hosp, Dept Neurosurg, Enshi, Peoples R China; [Li, Xiang] Wuhan Univ, Med Res Inst, Wuhan, Peoples R China"

通信作者："Wei, W; Li, X (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Neurosurg, Wuhan, Peoples R China.; Wei, W; Li, X (通讯作者)，Wuhan Univ, Zhongnan Hosp, Brain Res Ctr, Wuhan, Peoples R China.; Li, X (通讯作者)，Wuhan Univ, Med Res Inst, Wuhan, Peoples R China."

来源：FRONTIERS IN NEUROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000979899500001

JCR分区：Q2

影响因子：2.7

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：TNF-related risk signature; glioblastoma multiforme; immune; biomarker; prognosis

摘要："BackgroundTumor necrosis factor (TNF) is an inflammatory cytokine that can coordinate tissue homeostasis by co-regulating the production of cytokines, cell survival, or death. It widely expresses in various tumor tissues and correlates with the malignant clinical features of patients. As an important inflammatory factor, the role of TNF alpha is involved in all steps of tumorigenesis and development, including cell transformation, survival, proliferation, invasion and metastasis. Recent research has showed that long non-coding RNAs (lncRNAs), defined as RNA transcripts >200 nucleotides that do not encode a protein, influence numerous cellular processes. However, little is known about the genomic profile of TNF pathway related-lncRNAs in GBM. This study investigated the molecular mechanism of TNF related-lncRNAs and their immune characteristics in glioblastoma multiforme (GBM) patients. MethodsTo identify TNF associations in GBM patients, we performed bioinformatics analysis of public databases - The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA). The ConsensusClusterPlus, CIBERSORT, Estimate, GSVA and TIDE and first-order bias correlation and so on approaches were conducted to comprehensively characterize and compare differences among TNF-related subtypes. ResultsBased on the comprehensive analysis of TNF-related lncRNAs expression profiles, we constructed six TNF-related lncRNAs (C1RL-AS1, LINC00968, MIR155HG, CPB2-AS1, LINC00906, and WDR11-AS1) risk signature to determine the role of TNF-related lncRNAs in GBM. This signature could divide GBM patients into subtypes with distinct clinical and immune characteristics and prognoses. We identified three molecular subtypes (C1, C2, and C3), with C2 showing the best prognosis; otherwise, C3 showing the worst prognosis. Moreover, we assessed the prognostic value, immune infiltration, immune checkpoints, chemokines cytokines and enrichment analysis of this signature in GBM. The TNF-related lncRNA signature was tightly associated with the regulation of tumor immune therapy and could serve as an independent prognostic biomarker in GBM. ConclusionThis analysis provides a comprehensive understanding of the role of TNF-related characters, which may improve the clinical outcome of GBM patients."

基金机构：National Natural Science Foundation of China [82001421]

基金资助正文：Funding This work was supported by grants from the National Natural Science Foundation of China (No. 82001421).