Novel bioactive dental restorations to inhibit secondary caries in enamel and dentin under oral biofilms

作者全名："Zhou, Wen; Chen, Hong; Weir, Michael D.; Oates, Thomas W.; Zhou, Xuedong; Wang, Suping; Cheng, Lei; Xu, Hockin H. K."

作者地址："[Zhou, Wen] Fujian Med Univ, Sch & Hosp Stomatol, Fujian Key Lab Oral Dis, Fuzhou 350002, Peoples R China; [Zhou, Wen] Fujian Med Univ, Fujian Prov Engn Res Ctr Oral Biomat, Fuzhou 350002, Peoples R China; [Zhou, Wen] Fujian Med Univ, Stomatol Key Lab Fujian Coll & Univ, Fuzhou 350002, Peoples R China; [Chen, Hong] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Dept Endodont,Chongqing Municipal Key Lab Oral Bi, Chongqing 401147, Peoples R China; [Weir, Michael D.; Oates, Thomas W.; Xu, Hockin H. K.] Univ Maryland, Dept Adv Oral Sci & Therapeut, Sch Dent, Baltimore, MD 21201 USA; [Zhou, Xuedong; Cheng, Lei] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Peoples R China; [Wang, Suping] Zhengzhou Univ, Affiliated Hosp 1, Stomatol Ctr, Zhengzhou 450052, Henan, Peoples R China; [Xu, Hockin H. K.] Univ Maryland, Ctr Stem Cell Biol & Regenerat Med, Sch Med, Baltimore, MD 21201 USA; [Xu, Hockin H. K.] Univ Maryland, Marlene & Stewart Greenebaum Canc Ctr, Sch Med, Baltimore, MD 21201 USA"

通信作者："Cheng, L (通讯作者)，Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Peoples R China.; Wang, SP (通讯作者)，Zhengzhou Univ, Affiliated Hosp 1, Stomatol Ctr, Zhengzhou 450052, Henan, Peoples R China."

来源：JOURNAL OF DENTISTRY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000979928700001

JCR分区：Q1

影响因子：4.8

年份：2023

卷号：133

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Bioactive restorations; Oral biofilms; Dental caries; Enamel and dentin; Antibacterial; Remineralization

摘要："Objective: To provide the first review on cutting-edge research on the development of new bioactive restorations to inhibit secondary caries in enamel and dentin under biofilms. State-of-the-art bioactive and therapeutic ma-terials design, structure-property relationships, performance and efficacies in oral biofilm models.Data, Sources and Study selection: Researches on development and assessment new secondary caries inhibition restorations via in vitro and in vivo biofilm-based secondary caries models were included. The search of articles was carried out in Web of Science, PubMed, Medline and Scopus.Conclusions: Based on the found articles, novel bioactive materials are divided into different categories according to their remineralization and antibacterial biofunctions. In vitro and in vivo biofilm-based secondary caries models are effective way of evaluating the materials efficacies. However, new intelligent and pH-responsive materials were still urgent need. And the materials evaluation should be performed via more clinical relevant biofilm-based secondary caries models.Clinical significance: Secondary caries is a primary reason for dental restoration failures. Biofilms produce acids, causing demineralization and secondary caries. To inhibit dental caries and improve the health and quality of life for millions of people, it is necessary to summarize the present state of technologies and new advances in dental biomaterials for preventing secondary caries and protecting tooth structures against oral biofilm attacks. In addition, suggestions for future studies are provided."

基金机构："National Natural Science Foundation of China [82071106, 82100991]; China Postdoctoral Science Foundation [2021M700627]; Natural Science Foundation of Fujian Province [2021J01798]"

基金资助正文：This work was supported by the National Natural Science Foundation of China (Grant Nos. 82071106 and 82100991) . China Postdoctoral Science Foundation (Grant No. 2021M700627) and Natural Science Foundation of Fujian Province (Grant No. 2021J01798) .