Dual mode imaging guided multi-functional bio-targeted oxygen production probes for tumor therapy

作者全名："Wang, Yaotai; Zhang, Zhong; Ren, Li; Luo, Yong; Wang, Qi; Zou, Jianzhong"

作者地址："[Wang, Yaotai; Zhang, Zhong; Ren, Li; Luo, Yong; Wang, Qi; Zou, Jianzhong] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China; [Wang, Yaotai; Wang, Qi; Zou, Jianzhong] Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing 400016, Peoples R China"

通信作者："Zou, JZ (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China.; Zou, JZ (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing 400016, Peoples R China."

来源：JOURNAL OF NANOBIOTECHNOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000980650200001

JCR分区：Q1

影响因子：10.6

年份：2023

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Bacteriotherapy; Tumor hypoxia; Focused ultrasound ablation surgery; Dual mode imaging; Anti-tumor therapy

摘要："Focused ultrasound ablation surgery (FUAS) is a novel therapy with a wide range of potential applications. However, synergists are crucial to the therapy process due to the ultrasonic energy's attenuation properties. As a result of the complex hypoxic environment in the tumor area and many factors, the existing synergists have limitations such as weak targeting, single imaging mode, and easy tumor recurrence after treatment. Because of the above deficiencies, this study intends to construct bio-targeted oxygen production probes consisting of Bifidobacterium that naturally target the hypoxia region of the tumor and multi-functional oxygen-producing nanoparticles equipped with IR780, perfluorohexane (PFH), CBP (carboplatin), and oxygen. The probes are expected to achieve targeted and synergistic FUAS therapy and dual-mode imaging to mediate tumor diagnosis and treatment. The oxygen and drugs carried in it are accurately released after FUAS stimulation, which is expected to alleviate tumor hypoxia, avoid tumor drug resistance, improve the effect of chemotherapy, and realize FUAS combined with chemotherapy antitumor therapy. This strategy is expected to make up for the deficiencies of existing synergists, improve the effectiveness and safety of treatment, and provide the foundation for future tumor therapy progress."

基金机构：Chongqing Graduate Scientific Research Innovation Project [CYB21194]; Chongqing Natural Science Foundation Post-doctoral Fund [cstc2021jcyj-bshX0169]

基金资助正文："This work was supported by the Chongqing Graduate Scientific Research Innovation Project (CYB21194), Chongqing Natural Science Foundation Post-doctoral Fund (cstc2021jcyj-bshX0169)."