A case of unexpected death due to primary angiitis of the central nervous system

作者全名："Yang, Li; Zheng, Zhe; Zeng, Yujie; Zhang, Shangyu; Jin, Pengyue; Li, Yongguo; Li, Jianbo; Tang, Renkuan"

作者地址："[Yang, Li; Zeng, Yujie; Zhang, Shangyu; Jin, Pengyue; Li, Yongguo; Li, Jianbo; Tang, Renkuan] Chongqing Med Univ, Coll Basic Med, Dept Forens Med, 1 Med Coll Rd, Chongqing 400010, Peoples R China; [Zheng, Zhe] Henan Univ Sci & Technol, Dept Forens Med, Luoyang 471023, Henan, Peoples R China"

通信作者："Li, JB; Tang, RK (通讯作者)，Chongqing Med Univ, Coll Basic Med, Dept Forens Med, 1 Med Coll Rd, Chongqing 400010, Peoples R China."

来源：FORENSIC SCIENCE MEDICINE AND PATHOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000981262600002

JCR分区：Q2

影响因子：1.5

年份：2023

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文献类型：Article; Early Access

关键词：Primary angiitis of the central nervous system; Pathological examination; Forensic medicine; Case report

摘要："Primary angiitis of the central nervous system (PACNS) is a rare and fatal cerebral vasculitis mainly involving the arteriole of the pia mater, cerebral cortex, and spinal cord. It has an insidious onset atypical symptoms. In this paper, we reported an unexpected death due to cerebral hemorrhage caused by PACNS. According to the typical clinical manifestations (headache, dizziness, weakness of the limbs, temporary blurred vision, etc.) and pathological examination (wide degeneration and fibrinoid necrosis of blood vessel walls with inflammatory cell infiltration), as well as hematoxylin-eosin staining, immunohistochemistry for CD15 + and gram staining, we finally determined that the patient died due to cerebral vascular rupture and hemorrhage caused by PACNS. This case illustrates the value and key points of autopsy in evaluating sudden deaths."

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