Exploration of the Shared Hub Genes and Biological Mechanism in Osteoporosis and Type 2 Diabetes Mellitus based on Machine Learning

作者全名："Zhao, Runhan; Xiong, Chuang; Zhao, Zenghui; Zhang, Jun; Huang, Yanran; Xie, Zhou; Qu, Xiao; Luo, Xiaoji; Li, Zefang"

作者地址："[Zhao, Runhan; Xiong, Chuang; Zhao, Zenghui; Zhang, Jun; Huang, Yanran; Xie, Zhou; Qu, Xiao; Luo, Xiaoji; Li, Zefang] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China; [Zhao, Runhan; Xiong, Chuang; Zhao, Zenghui; Zhang, Jun; Huang, Yanran; Xie, Zhou; Qu, Xiao; Luo, Xiaoji] Chongqing Med Univ, Orthoped Lab, Chongqing 400016, Peoples R China; [Li, Zefang] Qianjiang Cent Hosp Chongqing, Dept Orthoped, Chongqing 409000, Peoples R China"

通信作者："Luo, XJ; Li, ZF (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China.; Luo, XJ (通讯作者)，Chongqing Med Univ, Orthoped Lab, Chongqing 400016, Peoples R China.; Li, ZF (通讯作者)，Qianjiang Cent Hosp Chongqing, Dept Orthoped, Chongqing 409000, Peoples R China."

来源：BIOCHEMICAL GENETICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000981327900001

JCR分区：Q3

影响因子：2.1

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Osteoporosis; Type 2 Diabetes Mellitus; Machine Learning; Hub genes; Bioinformatics analysis

摘要："A substantial amount of evidence suggests a close relationship between osteoporosis (OP) and Type 2 Diabetes Mellitus (T2DM), but the mechanisms involved remain unknown. Therefore, we conducted this study with the aim of screening for hub genes common to both diseases and conducting a preliminary exploration of common regulatory mechanisms. In the present study, we first screened genes significantly associated with OP and T2DM by the univariate logistic regression algorithm. And then, based on cross-analysis and random forest algorithm, we obtained three hub genes (ACAA2, GATAD2A, and VPS35) and validated the critical roles and predictive performance of the three genes in both diseases by differential expression analysis, receiver operating characteristic (ROC) curves, and genome wide association study (GWAS) analysis. Finally, based on gene set enrichment analysis (GSEA) and the construction of the miRNA-mRNA regulatory network, we conducted a preliminary exploration of the co-regulatory mechanisms of three hub genes in two diseases. In conclusion, this study provides promising biomarkers for predicting and treating both diseases and offers novel directions for exploring the common regulatory mechanisms of both diseases."

基金机构："Natural Science Foundation of Chongqing, China [cstc2021jcyj-msxmX0806]; Chongqing medical scientific research project (Joint project of Chong-qing Health Commission and Science and Technology Bureau) [2022QNXM058]"

基金资助正文："This research was partially supported by Natural Science Foundation of Chongqing, China (No. cstc2021jcyj-msxmX0806) and Chongqing medical scientific research project (Joint project of Chong-qing Health Commission and Science and Technology Bureau, No. 2022QNXM058)."