"The combination of a prolonged treatment time window and alpha-fetoprotein benefits the tumor response of hepatocellular carcinoma patients as evaluated by the imRECIST: a single-center, retrospective study"

作者全名："Yin, Kun-Li; Li, Ming; Liao, Rui; Shi, Zheng-Rong; Qiu, Jian-Guo; Lan, Xiang; Duan, Yu-Xin; Ye, Wen-Tao; Wu, Zhou-Yu; Du, Cheng-You; Xiao, Heng"

作者地址："[Yin, Kun-Li; Li, Ming; Liao, Rui; Shi, Zheng-Rong; Qiu, Jian-Guo; Lan, Xiang; Duan, Yu-Xin; Ye, Wen-Tao; Wu, Zhou-Yu; Du, Cheng-You; Xiao, Heng] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing, Peoples R China; [Du, Cheng-You; Xiao, Heng] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Du, CY; Xiao, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF GASTROINTESTINAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000981984800001

JCR分区：Q3

影响因子：2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Hepatocellular carcinoma (HCC); immunotherapy; immune checkpoint blockade; pseudoprogression; alpha-fetoprotein

摘要："Background: The combined immunotargeting therapy of hepatocellular carcinoma (HCC) have brought remarkable results. There are still some drawbacks to the application of the immune-modified Response Evaluation Criteria in Solid Tumors to Immunotherapy (imRECIST). How many weeks does it take to confirm the true disease progression for HCC patients who had reported disease progression for the first time based on imRECIST. Whether alpha-fetoprotein (AFP), an important indicator in the progression and prognosis of liver cancer, has the same value in immunotherapy. This prompted more clinical data to gather evidence that the immunotherapy time window issue contradicts the potential benefit of therapy.Methods: This study retrospectively analyzed the clinical data of 32 patients who had undergone immunotherapy plus targeted therapy at the First Affiliated Hospital of Chongqing Medical University from June 2019 to June 2022. ImRECIST was used to evaluate the therapeutic efficacy among the patients. Before initial treatment and each immunotherapy cycle, each patient underwent standard abdominal computed tomography (CT) imaging and some biochemical indicators to assess physical condition and tumor response. All patients included will be divided into 8 groups. The differences in the survival outcomes of each treatment group were analysed.Results: Among the 32 advanced HCC patients, 9 patients achieved stable disease (SD), 12 patients showed progressive disease (PD), 3 patients showed a complete response (CR), and 8 patients showed a partial response (PR). There is no difference in baseline characteristics between subgroups. In relation to patients with PD, a prolonged therapeutic time window and the provision of continuous medication may lead to a PR, prolonging their overall survival (P=0.5864). Compared to the patients with continuous PD, there was no significant difference in the survival of patients with increased AFP concentrations after treatment who achieved PR or SD and ultimately showed PD (P=0.6600).Conclusions: In our study, the time window for treatment may need to be extended in the process of immunotherapy for HCC patients. An analysis of AFP may assist the imRECIST by providing a more accurate evaluation of tumor progression."

基金机构："National Natural Science Foundation of China [81703063, 81702408]; Science and Health Joint Research Project of Chongqing Municipality [2020GDRC013]"

基金资助正文："Funding: This study was funded by the National Natural Science Foundation of China (No. 81703063, No. 81702408) , and the Science and Health Joint Research Project of Chongqing Municipality (No. 2020GDRC013) ."