Association Between HLA Polymorphisms and Sympathetic Ophthalmia in Han Chinese

作者全名："Zhao, Tingting; Cao, Qingfeng; Zhou, Chunjiang; Wang, Yao; Du, Liping; Yang, Peizeng"

作者地址："[Zhao, Tingting; Cao, Qingfeng; Zhou, Chunjiang; Wang, Yao; Yang, Peizeng] Chongqing Med Univ, Chongqing Key Lab Ophthalmol, Chongqing Branch, Chongqing Eye Inst,Affiliated Hosp 1,Municipal Div, Chongqing, Peoples R China; [Du, Liping] Zhengzhou Univ, Henan Prov Eye Hosp, Henan Int Joint Res Lab Ocular Immunol & Retinal I, Dept Ophthalmol,Affiliated Hosp 1, Zhengzhou, Peoples R China; [Yang, Peizeng] Chongqing Med Univ, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China"

通信作者："Yang, PZ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China."

来源：OCULAR IMMUNOLOGY AND INFLAMMATION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000982406600001

JCR分区：Q2

影响因子：2.6

年份：2023

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期号：　

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文献类型：Article; Early Access

关键词：Allele; haplotype; HLA; polymorphism; sympathetic ophthalmia

摘要："PurposeSympathetic ophthalmia (SO) is considered as an autoimmune disease with unclear mechanisms. This study investigated the relationship between HLA polymorphisms and SO.MethodsHLA typing was performed using the LABType reverse SSO DNA typing method. The allele and haplotype frequencies were assessed using the PyPop software. Statistical significance of genotype distributions between 116 patients and 84 healthy individuals (control) was determined using Fisher's exact test or Pearson's chi-squared test.ResultsThe SO group had a higher frequency of HLA-DRB1 * 04:05, HLA-DQB1 * 04:01, DRB1 * 04:05-DQB1 * 04:01 haplotype as compared to the control group (Pc < 0.001 for all).ConclusionThis study revealed that DRB1 * 04:05 and DQB1 * 04:01 alleles, as well as DRB1 * 04:05-DQB1 * 04:01 haplotye could be potential risk factors for SO."

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