Prognostic factors of childhood acute lymphoblastic leukemia with TCF3::PBX1 in CCCG-ALL-2015: A multicenter study

作者全名："Zhang, Honghong; Wan, Yang; Wang, Hongsheng; Cai, Jiaoyang; Yu, Jie; Hu, Shaoyan; Fang, Yongjun; Gao, Ju; Jiang, Hua; Yang, Minghua; Liang, Changda; Jin, Runming; Tian, Xin; Ju, Xiuli; Hu, Qun; Jiang, Hui; Li, Zhifan; Wang, Ningling; Sun, Lirong; Leung, Alex W. K.; Wu, Xuedong; Qian, Xiaowen; Qian, Maoxiang; Li, Chi-kong; Yang, Jun; Tang, Jingyan; Zhu, Xiaofan; Shen, Shuhong; Zhang, Li; Pui, Ching-Hon; Zhai, Xiaowen"

作者地址："[Zhang, Honghong; Wang, Hongsheng; Qian, Xiaowen; Qian, Maoxiang; Zhai, Xiaowen] Fudan Univ, Childrens Natl Med Ctr, Childrens Hosp, Dept Hematol Oncol, Shanghai, Peoples R China; [Wan, Yang; Zhu, Xiaofan; Zhang, Li] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Expt Hematol, Inst Hematol & Blood Dis Hosp,Dept Pediat, Haihe Lab Cell Ecosyst,Natl Clin Res Ctr Blood Di, Tianjin, Peoples R China; [Cai, Jiaoyang; Tang, Jingyan; Shen, Shuhong] Shanghai Jiao Tong Univ, Key Lab Pediat Hematol & Oncol, Shanghai Childrens Med Ctr, Sch Med,Natl Hlth Comm,Dept Hematol Oncol, Shanghai, Peoples R China; [Yu, Jie] Chongqing Med Univ, Affiliated Childrens Hosp, Dept Hematol Oncol, Chongqing, Peoples R China; [Hu, Shaoyan] Soochow Univ, Childrens Hosp, Dept Hematol Oncol, Suzhou, Peoples R China; [Fang, Yongjun] Nanjing Med Univ, Childrens Hosp, Dept Hematol Oncol, Nanjing, Peoples R China; [Gao, Ju] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, West China Univ Hosp 2, Dept Pediat,Minist Educ, Chengdu, Peoples R China; [Jiang, Hua] Guangzhou Women & Childrens Med Ctr, Dept Hematol Oncol, Guangzhou, Peoples R China; [Yang, Minghua] Cent South Univ, Xiangya Hosp, Dept Pediat, Changsha, Peoples R China; [Liang, Changda] Jiangxi Prov Childrens Hosp, Dept Hematol Oncol, Nanchang, Jiangxi, Peoples R China; [Jin, Runming] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Pediat, Wuhan, Peoples R China; [Tian, Xin] KunMing Childrens Hosp, Dept Hematol Oncol, Kunming, Yunnan, Peoples R China; [Ju, Xiuli] Shandong Univ, Qilu Hosp, Dept Pediat, Jinan, Peoples R China; [Hu, Qun] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pediat, Wuhan, Peoples R China; [Jiang, Hui] Shanghai Jiao Tong Univ, Childrens Hosp, Dept Hematol Oncol, Shanghai, Peoples R China; [Li, Zhifan] Xian Northwest Womens & Childrens Hosp, Dept Hematol Oncol, Xian, Peoples R China; [Wang, Ningling] Anhui Med Univ, Affiliated Hosp 2, Dept Pediat, Hefei, Anhui, Peoples R China; [Sun, Lirong] Qingdao Univ, Affiliated Hosp, Dept Pediat, Qingdao, Peoples R China; [Leung, Alex W. K.; Li, Chi-kong] Chinese Univ Hong Kong, Hong Kong Childrens Hosp, Dept Pediat, Hong Kong, Peoples R China; [Wu, Xuedong] Southern Med Univ, Nanfang Hosp, Dept Pediat, Guangzhou, Peoples R China; [Yang, Jun; Pui, Ching-Hon] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN USA; [Yang, Jun; Pui, Ching-Hon] St Jude Childrens Res Hosp, Dept Global Pediat Med, Memphis, TN USA; [Yang, Jun; Pui, Ching-Hon] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN USA"

通信作者："Zhai, XW (通讯作者)，Fudan Univ, Childrens Hosp, Dept Hematol Oncol, 399 Wanyuan Rd, Shanghai 201102, Peoples R China.; Pui, CH (通讯作者)，St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA.; Shen, SH (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Dept Hematol Oncol, 1678 Dongfang Rd, Shanghai 200127, Peoples R China.; Zhang, L (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Dept Pediat, Inst Hematol & Blood Dis Hosp, 288 Nanjing Rd, Tianjin 300020, Peoples R China."

来源：CANCER

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000982416000001

JCR分区：Q1

影响因子：6.1

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：acute lymphoblastic leukemia; event-free survival; prognostic factor; TCF3; PBX1

摘要："BackgroundContemporary risk-directed treatment has improved the outcome of patients with acute lymphoblastic leukemia (ALL) and TCF3::PBX1 fusion. In this study, the authors seek to identify prognostic factors that can be used to further improve outcome. MethodsThe authors studied 384 patients with this genotype treated on Chinese Children's Cancer Group ALL-2015 protocol between January 1, 2015 and December 31, 2019. All patients provisionally received intensified chemotherapy in the intermediate-risk arm without prophylactic cranial irradiation; those with high minimal residual disease (MRD) >= 1% at day 46 (end) of remission induction were candidates for hematopoietic cell transplantation. ResultsThe overall 5-year event-free survival was 84.4% (95% confidence interval [CI], 80.6-88.3) and 5-year overall survival 88.9% (95% CI, 85.5-92.4). Independent factors associated with lower 5-year event-free survival were male sex (80.4%, [95% CI, 74.8-86.4] vs. 88.9%, [95% CI, 84.1-93.9] in female, p = .03) and positive day 46 MRD (>= 0.01%) (62.1%, [95% CI, 44.2-87.4] vs. 87.1%, [95% CI, 83.4-90.9] in patients with negative MRD, p < .001). The presence of testicular leukemia at diagnosis (n = 10) was associated with particularly dismal 5-year event-free survival (33.3% [95% CI, 11.6-96.1] vs. 83.0% [95% CI, 77.5-88.9] in the other 192 male patients, p < .001) and was an independent risk factor (hazard ratio [HR], 5.7; [95% CI, 2.2-14.5], p < .001). ConclusionsThese data suggest that the presence of positive MRD after intensive remission induction and testicular leukemia at diagnosis are indicators for new molecular therapeutics or immunotherapy in patients with TCF3::PBX1 ALL."

基金机构："National Natural Science Foundation of China [81670136, 82141125]; Science and Technology Commission of Shanghai Municipality [21Y31900302]; VIVA China Children's Cancer Foundation; Shanghai Sailing Program, Science and Technology Commission of Shanghai Municipality [20YF1403000]; Cyrus Tang~Foundation [ZSBK0070]; Shanghai Fudan University Education Development Foundation [ZSBK0046]; Shanghai Hospital Development Center [SHDC12019121]; American Lebanese Syrian Associated Charities"

基金资助正文："National Natural Science Foundation of China, Grant/Award Numbers: 81670136, 82141125; Science and Technology Commission of Shanghai Municipality, Grant/Award Number: 21Y31900302; VIVA China Children's Cancer Foundation; Shanghai Sailing Program, Science and Technology Commission of Shanghai Municipality, Grant/Award Number: 20YF1403000; Cyrus Tang Foundation, Grant/Award Number: ZSBK0070; Shanghai Fudan University Education Development Foundation, Grant/Award Number: ZSBK0046; Shanghai Hospital Development Center, Grant/Award Number: SHDC12019121; American Lebanese Syrian Associated Charities"