Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study

作者全名："Zhang, Yajuan; Huang, Chu-Chung; Zhao, Jiajia; Liu, Yuchen; Xia, Mingrui; Wang, Xiaoqin; Wei, Dongtao; Chen, Yuan; Liu, Bangshan; Zheng, Yanting; Wu, Yankun; Chen, Taolin; Cheng, Yuqi; Xu, Xiufeng; Gong, Qiyong; Si, Tianmei; Qiu, Shijun; Cheng, Jingliang; Tang, Yanqing; Wang, Fei; Qiu, Jiang; Xie, Peng; Li, Lingjiang; He, Yong; Lin, Ching-Po; Lo, Chun-Yi Zac"

作者地址："[Zhang, Yajuan; Zhao, Jiajia; Liu, Yuchen] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai 200433, Peoples R China; [Zhang, Yajuan] ShanghaiTech Univ, Sch Biomed Engn, Shanghai, Peoples R China; [Huang, Chu-Chung] East China Normal Univ, Affiliated Mental Hlth Ctr ECNU, Sch Psychol & Cognit Sci, Shanghai Key Lab Brain Funct Genom, Shanghai, Peoples R China; [Huang, Chu-Chung] Shanghai Changning Mental Hlth Ctr, Shanghai, Peoples R China; [Xia, Mingrui; He, Yong] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China; [Xia, Mingrui; He, Yong] Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connect, Beijing, Peoples R China; [Xia, Mingrui; He, Yong] Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China; [Wang, Xiaoqin; Wei, Dongtao] Minist Educ, Key Lab Cognit & Personal SWU, Chongqing, Peoples R China; [Wang, Xiaoqin; Wei, Dongtao] Southwest Univ, Dept Psychol, Chongqing, Peoples R China; [Chen, Yuan] Zhengzhou Univ, Dept Magnet Resonance Imaging, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Liu, Bangshan; Li, Lingjiang] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China; [Liu, Bangshan; Li, Lingjiang] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China; [Liu, Bangshan; Li, Lingjiang; DIDA-Major Depressive Disorder] Cent South Univ, China Natl Technol Inst Mental Disorders, Hunan Med Ctr Mental Hlth, Hunan Key Lab Psychiat & Mental Hlth,Mental Hlth, Changsha, Hunan, Peoples R China; [Zheng, Yanting; Qiu, Shijun] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Radiol, Guangzhou, Peoples R China; [Wu, Yankun; Si, Tianmei] Peking Univ, Peking Univ Sixth Hosp, Peking Univ Inst Mental Hlth, NHC Key Lab Mental Hlth,Natl Clin Res Ctr Mental, Beijing, Peoples R China; [Chen, Taolin; Gong, Qiyong] Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Dept Radiol, Chengdu, Peoples R China; [Chen, Taolin; Gong, Qiyong] Chinese Acad Med Sci, Res Unit Psychoradiol, Chengdu, Sichuan, Peoples R China; [Cheng, Yuqi; Xu, Xiufeng] Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming, Peoples R China; [Tang, Yanqing; Wang, Fei] China Med Univ, Dept Psychiat, Affiliated Hosp 1, Shenyang, Peoples R China; [Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, NHC Key Lab Diag & Treatment Brain Funct Dis, Chongqing, Peoples R China; [Xie, Peng] Chongqing Key Lab Neurobiol, Chongqing, Peoples R China; [He, Yong] Inst Brain Res, Beijing, Peoples R China; [Lin, Ching-Po] Natl Yang Ming Chiao Tung Univ, Inst Neurosci, Taipei 11221, Taiwan; [Lo, Chun-Yi Zac] Chung Yuan Christian Univ, Dept Biomed Engn, Taoyuan 32023, Taiwan"

通信作者："Huang, CC (通讯作者)，East China Normal Univ, Affiliated Mental Hlth Ctr ECNU, Sch Psychol & Cognit Sci, Shanghai Key Lab Brain Funct Genom, Shanghai, Peoples R China.; Huang, CC (通讯作者)，Shanghai Changning Mental Hlth Ctr, Shanghai, Peoples R China.; Lo, CYZ (通讯作者)，Chung Yuan Christian Univ, Dept Biomed Engn, Taoyuan 32023, Taiwan."

来源：NEUROIMAGE-CLINICAL

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000982926200001

JCR分区：Q2

影响因子：3.4

年份：2023

卷号：37

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Serotonin; Dorsal and median raphe nuclei; Seed-based analysis; Resting-state fMRI data; Functional connectivity; Multicenter

摘要："Accumulating evidence showed that major depressive disorder (MDD) is characterized by a dysfunction of serotonin neurotransmission. Raphe nuclei are the sources of most serotonergic neurons that project throughout the brain. Incorporating measurements of activity within the raphe nuclei into the analysis of connectivity characteristics may contribute to understanding how neurotransmitter synthesized centers are involved in the pathogenesis of MDD. Here, we analyzed the resting-state functional magnetic resonance imaging (RS-fMRI) dataset from 1,148 MDD patients and 1,079 healthy individuals recruited across nine centers. A seed-based analysis with the dorsal raphe and median raphe nuclei was performed to explore the functional connectivity (FC) alterations. Compared to controls, for dorsal raphe, the significantly decreased FC linking with the right precuneus and median cingulate cortex were found; for median raphe, the increased FC linking with right su-perior cerebellum (lobules V/VI) was found in MDD patients. In further exploratory analyzes, MDD-related connectivity alterations in dorsal and median raphe nuclei in different clinical factors remained highly similar to the main findings, indicating these abnormal connectivities are a disease-related alteration. Our study high-lights a functional dysconnection pattern of raphe nuclei in MDD with multi-site big data. These findings help improve our understanding of the pathophysiology of depression and provide evidence of the theoretical foundation for the development of novel pharmacotherapies."

基金机构："Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]; 111 Project [09002344]; National Natural Science Foundation of China [82071998, 81671767, 82021004, 81620108016, 91432115, 81171286, 91232714, 31771231, 31271087, 81571331, 81271499, 81571311, 81920108019, 91649117, 81771344, 81471251, 81630031, 81621003, 81660237, 17JC1404105]; Shanghai Science and Technology Innovation Plan [17JC1404101, Z191100001119023]; Beijing Nova Program [2020NTST29]; Fundamental Research Funds for the Central Universities [2018YFA0701400]; National Key R & D Program of China [T2015027]; Changjiang Scholar Professorship Award [2013CB835100]; National Basic Research Program of China [2015AA020513]; ZJ Lab [201701011]; Natural Science Foundation of Chongqing; Shanghai Center for Brain Science and Brain-Inspired Technology [B18015]; National High Tech Development Plan (863); STI2030-Major Projects [2018-1002-SF-0442]; Medical Science and Technology Research Project of Henan Province; National Science and Technologic Program of China; Science and Technology Plan Project of Guangzhou; Guangzhou Key Laboratory; [82201720]; [cstc2019jcyj-msxmX0520]; [2022ZD0213400]; [2015BAI13B02]"

基金资助正文："This work was supported by Shanghai Municipal Science and Technology Major Project (No.2018SHZDZX01) , ZJ Lab, and Shanghai Center for Brain Science and Brain-Inspired Technology, the 111 Project (No.B18015) , STI2030-Major Projects (2022ZD0213400) , the National Natural Science Foundation of China (82201720; 82071998; 81671767; 82021004; 81620108016; 91432115; 81171286; 91232714; 31771231; 31271087; 81571331; 81271499; 81571311; 81920108019; 91649117; 81771344; 81471251; 81630031; 81621003; 81660237) , Shanghai Science and Technology Innovation Plan (17JC1404105 and 17JC1404101) , the Beijing Nova Program (Z191100001119023) , Fundamental Research Funds for the Central Universities (2020NTST29) , the National Key R & D Program of China (2018YFA0701400) , the Changjiang Scholar Professorship Award (T2015027) , the National Science and Technologic Program of China (2015BAI13B02) , the National Basic Research Program of China (2013CB835100) , the Natural Science Foundation of Chongqing (cstc2019jcyj-msxmX0520), the National High Tech Development Plan (863) (2015AA020513) , the Medical Science and Technology Research Project of Henan Province (201701011), Science and Technology Plan Project of Guangzhou (2018-1002-SF-0442) and Guangzhou Key Laboratory (09002344). DIDA-MDD Working Group: Yong He, Lingjiang Li, Jingliang Cheng, Qiyong Gong, Ching-Po Lin, Jiang Qiu, Shijun Qiu, Tianmei Si, Yanqing Tang, Fei Wang, Peng Xie, Xiufeng Xu & Mingrui Xia."