Syntaxin 7 modulates seizure activity in epilepsy

作者全名："Wu, Junhong; Zhang, Hui; Yang, Liu; Chen, Yuanyuan; Li, Jiyuan; Yang, Min; Zhang, Xiaogang; He, Changlong; Wang, Xuefeng; Xu, Xin"

作者地址："[Wu, Junhong; Zhang, Hui; Yang, Liu; Chen, Yuanyuan; Yang, Min; Zhang, Xiaogang; Wang, Xuefeng; Xu, Xin] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing Key Lab Neurol, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Li, Jiyuan] Shanxi Med Univ, Hosp 1, Dept Neurol, 85 Jiefang South Rd, Taiyuan, Shanxi, Peoples R China; [Zhang, Xiaogang] Chongqing Gen Hosp, Dept Neurol, Chongqing Key Lab Neurodegenerat Dis, Liangjiang New Area, 118 Xingguang Ave, Chongqing 401147, Peoples R China; [He, Changlong] Peoples Hosp Jiulongpo Dist, Dept Lab Med, Chongqing 400016, Peoples R China; [He, Changlong] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing 400016, Peoples R China"

通信作者："Wang, XF; Xu, X (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing Key Lab Neurol, 1 Youyi Rd, Chongqing 400016, Peoples R China.; He, CL (通讯作者)，Peoples Hosp Jiulongpo Dist, Dept Lab Med, Chongqing 400016, Peoples R China.; He, CL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing 400016, Peoples R China."

来源：NEUROBIOLOGY OF DISEASE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000983073300001

JCR分区：Q1

影响因子：5.1

年份：2023

卷号：181

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Syntaxin 7; Epilepsy; Synaptic transmission; Synaptic vesicle; GABA

摘要："The exact pathogenesis of epilepsy, one of the most common and devastating diseases of the nervous system, is not fully understood. Syntaxin7 (STX7) is a member of the SNARE superfamily, which mediates membrane fusion events in all cells. However, the role STX7 plays in epilepsy remains unclear. Therefore, this study investigates the role of STX7 in epilepsy. Our study found that the expression of STX7 was reduced in the epileptic brain and that overexpression of STX7 decreased the susceptibility to epileptic seizures and alleviated epileptic activity in a kainic acid-induced model and pentylenetetrazole-induced kindling model of epilepsy, whereas the down -regulation of STX7 showed opposite effects. Whole-cell patch-clamp recordings showed that STX7 does not affect the intrinsic excitability of neurons, but rather the excitation/inhibition ratio mediated by affecting the release of presynaptic gamma-aminobutyric acid neurotransmitters. Transmission electron microscopy results showed that STX7 did not affect the density of inhibitory synapses but could affect the density of inhibitory vesicles. Taken together, these results reveal a previously unknown function of STX7 in epilepsy and suggest that STX7 may serve as a novel target for epilepsy therapy."

基金机构：National Natural ScienceFoundation of China [82171440]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0058]

基金资助正文：Funding This work was supported by grants from the National Natural ScienceFoundation of China (82171440) and Natural Science Foundation of Chongqing (cstc2020jcyj-msxmX0058) .