Heat shock protein: a double-edged sword linking innate immunity and hepatitis B virus infection

作者全名："Dai, Wen-ying; Yao, Guo-qing; Deng, Xi-chuan; Zang, Guang-chao; Liu, Jia; Zhang, Guang-yuan; Chen, Yu-meng; Lv, Ming-qi; Chen, Ting-ting"

作者地址："[Dai, Wen-ying; Yao, Guo-qing; Zang, Guang-chao; Zhang, Guang-yuan; Chen, Yu-meng; Lv, Ming-qi; Chen, Ting-ting] Chongqing Med Univ, Lab Teaching & Management Ctr, Lab Tissue & Cell Biol, Chongqing 400016, Peoples R China; [Dai, Wen-ying; Chen, Yu-meng] Chongqing Med Univ, Coll Basic Med, Chongqing 400016, Peoples R China; [Deng, Xi-chuan; Liu, Jia; Zhang, Guang-yuan; Chen, Ting-ting] Chongqing Med Univ, Lab Teaching & Management Ctr, Pathogen Biol & Immunol Lab, Chongqing 400016, Peoples R China"

通信作者："Lv, MQ; Chen, TT (通讯作者)，Chongqing Med Univ, Lab Teaching & Management Ctr, Lab Tissue & Cell Biol, Chongqing 400016, Peoples R China."

来源：JOURNAL OF VIRUS ERADICATION

ESI学科分类：　

WOS号：WOS:000983596000001

JCR分区：Q2

影响因子：3.5

年份：2023

卷号：9

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Hepatitis B virus; HSPs; Antiviral; Vaccine adjuvant; Molecular chaperones

摘要："Heat shock proteins (HSPs), which have a variety of functions, are one of the stress protein families. In recent years, They have been reported to play a dual role in hepatitis B virus (HBV) which as persistent infection which is associated with, cirrhosis and liver cancer. In this article, we have summarized the regulatory mechanisms between HSPs and viruses, especially HBV and associated diseases based on HSP biological functions of in response to viral infections. In view of their potential as broad-spectrum antiviral targets, we have also discuss current progress and challenges in drug development based on HSPs, as well as the potential applications of agents that have been evaluated clinically in HBV treatment."

基金机构："Science and Technology Planning Project of Yuzhong District of Chongqing City [2020050]; Chongqing Municipal Education Commission Foundation [KJQN202000403]; General Project of Chongqing Natural Science Foundation [cstc2021jcyj-msxmX0095]; Chongqing Medical Uni-versity Undergraduate Innovation Experiment Project [LTMC202103, LTMCMTS202121]"

基金资助正文："Acknowledgement This work was supported by the Science and Technology Planning Project of Yuzhong District of Chongqing City, 2020050, and the Chongqing Municipal Education Commission Foundation, KJQN202000403, and the General Project of Chongqing Natural Science Foundation, cstc2021jcyj-msxmX0095, and Chongqing Medical Uni-versity Undergraduate Innovation Experiment Project (approvalnumbers LTMC202103 and LTMCMTS202121) . We gratefully thank the American Journal Experts for editing this manuscript."