MicroRNA regulation of phenotypic transformations in vascular smooth muscle: relevance to vascular remodeling

作者全名："Wang, Gang; Luo, Yulin; Gao, Xiaojun; Liang, Yu; Yang, Feifei; Wu, Jianbo; Fang, Dan; Luo, Mao"

作者地址："[Wang, Gang; Gao, Xiaojun; Wu, Jianbo; Fang, Dan; Luo, Mao] Southwest Med Univ, Drug Discovery Res Ctr, Sect 1, Key Lab Med Electrophysiol,Minist Educ, 1,Xianglin Rd, Luzhou, Sichuan, Peoples R China; [Wang, Gang; Gao, Xiaojun; Wu, Jianbo; Fang, Dan; Luo, Mao] Southwest Med Univ, Sch Pharm, Lab Cardiovasc Pharmacol, Dept Pharmacol, Luzhou, Sichuan, Peoples R China; [Wang, Gang; Yang, Feifei] Chongqing Med Univ, Sch Pharm, Chongqing, Peoples R China; [Luo, Yulin] Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, GCP Ctr, Luzhou, Peoples R China; [Liang, Yu; Luo, Mao] Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, Integrated Tradit Chinese & Western Med, Luzhou, Sichuan, Peoples R China"

通信作者："Fang, D; Luo, M (通讯作者)，Southwest Med Univ, Drug Discovery Res Ctr, Sect 1, Key Lab Med Electrophysiol,Minist Educ, 1,Xianglin Rd, Luzhou, Sichuan, Peoples R China.; Fang, D; Luo, M (通讯作者)，Southwest Med Univ, Sch Pharm, Lab Cardiovasc Pharmacol, Dept Pharmacol, Luzhou, Sichuan, Peoples R China.; Luo, M (通讯作者)，Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, Integrated Tradit Chinese & Western Med, Luzhou, Sichuan, Peoples R China."

来源：CELLULAR AND MOLECULAR LIFE SCIENCES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000984512800001

JCR分区：Q1

影响因子：6.2

年份：2023

卷号：80

期号：6

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结束页：　

文献类型：Review

关键词：miRNA; VSMC; Phenotypic transformation; Contractile phenotype; Synthetic phenotype

摘要："Alterations in the vascular smooth muscle cells (VSMC) phenotype play a critical role in the pathogenesis of several cardiovascular diseases, including hypertension, atherosclerosis, and restenosis after angioplasty. MicroRNAs (miRNAs) are a class of endogenous noncoding RNAs (approximately 19-25 nucleotides in length) that function as regulators in various physiological and pathophysiological events. Recent studies have suggested that aberrant miRNAs' expression might underlie VSMC phenotypic transformation, appearing to regulate the phenotypic transformations of VSMCs by targeting specific genes that either participate in the maintenance of the contractile phenotype or contribute to the transformation to alternate phenotypes, and affecting atherosclerosis, hypertension, and coronary artery disease by altering VSMC proliferation, migration, differentiation, inflammation, calcification, oxidative stress, and apoptosis, suggesting an important regulatory role in vascular remodeling for maintaining vascular homeostasis. This review outlines recent progress in the discovery of miRNAs and elucidation of their mechanisms of action and functions in VSMC phenotypic regulation. Importantly, as the literature supports roles for miRNAs in modulating vascular remodeling and for maintaining vascular homeostasis, this area of research will likely provide new insights into clinical diagnosis and prognosis and ultimately facilitate the identification of novel therapeutic targets."

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