Glycyrrhizin ameliorates impaired glucose metabolism and ovarian dysfunction in a polycystic ovary syndrome mouse model

作者全名："Yang, Jun-Pu; Ullah, Amin; Su, Ya-Nan; Otoo, Antonia; Adu-Gyamfi, Enoch Appiah; Feng, Qian; Wang, Ying-Xiong; Wang, Mei-Jiao; Ding, Yu-Bin"

作者地址："[Yang, Jun-Pu; Ullah, Amin; Su, Ya-Nan; Otoo, Antonia; Wang, Ying-Xiong; Wang, Mei-Jiao; Ding, Yu-Bin] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Adu-Gyamfi, Enoch Appiah] Iowa State Univ, Dept Genet, Ames, IA USA; [Feng, Qian] Chongqing Hosp Tradit Chinese Med, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Wang, Ying-Xiong; Wang, Mei-Jiao] Chongqing Med Univ, Dept Physiol, Chongqing, Peoples R China; [Ding, Yu-Bin] Chongqing Med Univ, Dept Toxicol, Chongqing, Peoples R China; [Ding, Yu-Bin] Changsha Med Univ, Dept Pharmacol, Changsha, Peoples R China; [Wang, Ying-Xiong; Wang, Mei-Jiao; Ding, Yu-Bin] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, 120 Longshan Rd, Chongqing 401147, Peoples R China"

通信作者："Wang, YX; Wang, MJ; Ding, YB (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, 120 Longshan Rd, Chongqing 401147, Peoples R China."

来源：BIOLOGY OF REPRODUCTION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000985852400001

JCR分区：Q2

影响因子：3.1

年份：2023

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期号：　

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文献类型：Article; Early Access

关键词：polycystic ovary syndrome; glycyrrhizin; high mobility group box 1; insulin resistance; ovarian dysfunction

摘要："Glycyrrhizin could improve inflammation, glucose metabolic disorders, and ovarian dysfunction in polycystic ovary syndrome mice by inhibiting the expression of high mobility group box 1. The aim of this study was to determine the impact of glycyrrhizin, an inhibitor of high mobility group box 1, on glucose metabolic disorders and ovarian dysfunction in mice with polycystic ovary syndrome. We generated a polycystic ovary syndrome mouse model by using dehydroepiandrosterone plus high-fat diet. Glycyrrhizin (100 mg/kg) was intraperitoneally injected into the polycystic ovary syndrome mice and the effects on body weight, glucose tolerance, insulin sensitivity, estrous cycle, hormone profiles, ovarian pathology, glucolipid metabolism, and some molecular mechanisms were investigated. Increased number of cystic follicles, hormonal disorders, impaired glucose tolerance, and decreased insulin sensitivity in the polycystic ovary syndrome mice were reverted by glycyrrhizin. The increased high mobility group box 1 levels in the serum and ovarian tissues of the polycystic ovary syndrome mice were also reduced by glycyrrhizin. Furthermore, increased expressions of toll-like receptor 9, myeloid differentiation factor 88, and nuclear factor kappa B as well as reduced expressions of insulin receptor, phosphorylated protein kinase B, and glucose transporter type 4 were restored by glycyrrhizin in the polycystic ovary syndrome mice. Glycyrrhizin could suppress the polycystic ovary syndrome-induced upregulation of high mobility group box 1, several inflammatory marker genes, and the toll-like receptor 9/myeloid differentiation factor 88/nuclear factor kappa B pathways, while inhibiting the insulin receptor/phosphorylated protein kinase B/glucose transporter type 4 pathways. Hence, glycyrrhizin is a promising therapeutic agent against polycystic ovary syndrome."

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