Cortical and subcortical morphological alterations in postpartum depression

作者全名："Yang, Wenqin; Jiang, Yihan; Ma, Lin; Xiao, Mengjia; Liu, Mingke; Ren, Zhanbing; Zhang, Yuanchao; Hu, Liangbo"

作者地址："[Yang, Wenqin; Ma, Lin; Xiao, Mengjia; Liu, Mingke; Hu, Liangbo] Chongqing Med Univ, Yongchuan Hosp, Dept Radiol, Chongqing 402160, Peoples R China; [Jiang, Yihan; Zhang, Yuanchao] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu 610054, Peoples R China; [Ren, Zhanbing] Shenzhen Univ, Coll Phys Educ, Shenzhen 518060, Peoples R China"

通信作者："Hu, LB (通讯作者)，Chongqing Med Univ, Yongchuan Hosp, Dept Radiol, Chongqing 402160, Peoples R China.; Zhang, YC (通讯作者)，Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu 610054, Peoples R China."

来源：BEHAVIOURAL BRAIN RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000986128500001

JCR分区：Q2

影响因子：2.6

年份：2023

卷号：447

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Postpartum depression; Cortical thickness; Local gyrification index; Subcortical; Magnetic resonance imaging

摘要："Postpartum depression (PPD) is the most common postpartum psychiatric disorder, which can negatively affect both mothers and their offspring. Although the functional changes of PPD have been extensively studied, little is known about its structural abnormalities. This study aimed to examine the cortical and subcortical morpho-logical abnormalities in PPD. High resolution T1 structural MRI data of 29 PPD women and 23 matched healthy postpartum women (HPW) were included in this study. Using surface-based morphometry, we examined the differences between the PPD and HPW group in the cortical thickness, local gyrification index and shape changes of deep gray matter nuclei. Compared with the HPW group, women with PPD showed significantly increased cortical thickness in the left superior frontal gyrus, cuneus and right lingual gyrus and fusiform gyrus, which correlated marginally with the EPDS scores of these subjects. In addition, women with PPD showed significant regional inflation in the right pallidum compared with the HPW group. These findings provided further evidence for the structural brain abnormalities in PPD."

基金机构：Natural Science Foundation project of Chongqing Science and Technology Bureau [CSTB2022NSCQ- MSX1035]; Key Project of Medical Research Program of Chongqing Health and Family Planning Commission [2017ZDXM020]; Postgraduate Innovation Fund Project of Chongq- ing Medical University [YJSCX202105]; High -level Scientific Research Foundation for the Introduction of Talent of Shenzhen University [RC00228]; Scientific Research Platform and Project of Colleges and Universities of Education Depart- ment of Guangdong Province [2022ZDZX2087]

基金资助正文：This work was supported by the Natural Science Foundation project of Chongqing Science and Technology Bureau (No:CSTB2022NSCQ- MSX1035) ; the Key Project of Medical Research Program of Chongqing Health and Family Planning Commission (grant number 2017ZDXM020) ; the Postgraduate Innovation Fund Project of Chongqing Medical University (grant number YJSCX202105) ; the High -level Scientific Research Foundation for the Introduction of Talent of Shenzhen University [grant number RC00228] ; and the Scientific Research Platform and Project of Colleges and Universities of Education Department of Guangdong Province (2022ZDZX2087) .