Imaging-based assessment of body composition in patients with Crohn's disease: a systematic review
作者全名："Tang, Wuli; Xie, Gang; Wang, Danni; Li, Ting; Ren, Yitao; Li, Junlin; Deng, Jiaxing; Li, Kang"
作者地址："[Tang, Wuli; Li, Kang] Chongqing Med Univ, Chongqing, Peoples R China; [Tang, Wuli] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China; [Tang, Wuli] Univ Chinese Acad Sci, Chongqing Sch, Chongqing, Peoples R China; [Tang, Wuli; Xie, Gang; Wang, Danni; Li, Ting; Ren, Yitao; Li, Junlin; Deng, Jiaxing; Li, Kang] Chongqing Gen Hosp, Dept Radiol, Chongqing, Peoples R China"
通信作者："Li, K (通讯作者)，Chongqing Med Univ, Chongqing, Peoples R China.; Li, K (通讯作者)，Chongqing Gen Hosp, Dept Radiol, Chongqing, Peoples R China."
来源：INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:000986352700002
JCR分区：Q1
影响因子：2.5
年份：2023
卷号：38
期号：1
开始页：
结束页：
文献类型：Review
关键词：Crohn's disease; Body composition; Nutritional status; Visceral fat; Skeletal muscle tissue; Imaging method
摘要："Background and aimsBody composition changes in patients with Crohn's disease (CD) have received increasing attention in recent years. This review aims to describe the changes in body composition in patients with CD on imaging and to analyze and summarize the prognostic value of body composition.MethodsWe systematically searched Web of Science, PubMed, Embase, Cochrane Library, and Medline via OVID for literature published before November 2022, and two researchers independently evaluated the quality of the retrieved literature.ResultsA total of 39 publications (32 cohort studies and 7 cross-sectional studies) involving 4219 patients with CD were retrieved. Imaging methods for body composition assessment, including dual-energy X-ray absorptiometry (DXA), computed tomography (CT) and magnetic resonance imaging (MRI), were included in this review. The study found that patients with CD typically have more visceral adipose tissue and less skeletal muscle mass, and the prevalence of sarcopenia and visceral obesity was significantly different in different studies (sarcopenia: 16-100%; visceral obesity: 5.3-30.5%). Available studies suggest that changes in the body composition of CD patients are significantly related to inflammatory status, disease behavior, poor outcomes, and drug efficacy.ConclusionAltered body composition can be a significant predictor of poor outcomes for CD patients. Therefore, the body composition of CD patients may serve as a potential therapeutic target to help optimize disease management strategies in clinical practice."
基金机构：Chongqing Science and Technology Bureau of Science and Technology Innovation and Application Development Special [cstc2020jscx-sbqwX0015]; Chongqing Postgraduate Research Innovation Project [CYS22391]
基金资助正文：This research was funded by the Chongqing Science and Technology Bureau of Science and Technology Innovation and Application Development Special (Grant No. cstc2020jscx-sbqwX0015) and Chongqing Postgraduate Research Innovation Project (Grant No. CYS22391).
