Comparison of thrombosis risk in an abdominal aortic dissection aneurysm with a double false lumen using computational fluid dynamic simulation method

作者全名："Chen, Hongbing; Su, Tong; Wang, Qi; Zheng, Zhe; Li, Hongwei; Li, Jianbo"

作者地址："[Chen, Hongbing; Wang, Qi; Zheng, Zhe; Li, Jianbo] Chongqing Med Univ, Dept Forens Med, Fac Basic Med Sci, Chongqing, Peoples R China; [Su, Tong] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing, Peoples R China; [Li, Hongwei] Chongqing Publ Bur, Tech Dept Interpol Corps, Chongqing, Peoples R China"

通信作者："Li, JB (通讯作者)，Chongqing Med Univ, Dept Forens Med, Coll Basic Med, Chongqing 400016, Peoples R China."

来源：TECHNOLOGY AND HEALTH CARE

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000987279600018

JCR分区：Q3

影响因子：1.4

年份：2023

卷号：31

期号：3

开始页：1003

结束页：1015

文献类型：Article

关键词：Abdominal aortic dissection aneurysm; CTA; computational fluid dynamics (CFD); thrombosis risk; patient-specific simulation

摘要："BACKGROUND: Aneurysms are associated with a mortality rate of 81% or more in cases of rupture. Intraluminal thrombus (ILT) is a common complication of aneurysms, it can greatly increase the risk of rupture. Especially for some of the more complex aneurysms, physicians need to consider the risk of thrombosis or progression and precisely formulate a treatment plan. Therefore, it is particularly important to assess the level of thrombosis risk through haemodynamics. OBJECTIVE: To analyse the haemodynamic indices and compare the thrombosis risk in a double false lumen abdominal aortic dissection aneurysm using computational fluid dynamics (CFD). METHODS: Computer tomography angiography (CTA) imaging data were collected from a patient with a double false lumen abdominal aortic dissection aneurysm, and three different lesion morphology aneurysm models were established, double false lumen abdominal aortic dissection aneurysm, single false lumen abdominal aortic dissection aneurysm and saccular abdominal aortic aneurysm, in order to analyse the flow velocity, time-averaged shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT) of blood flow, and endothelial cell activation potential (ECAP). RESULTS: All three aneurysms were in a low-flow state within the body, and the low-flow velocity flow in the proximal vessel wall extended to the right common iliac artery; the vortex intensity was more intense in the abdominal aortic dissection aneurysm than in the saccular abdominal aortic aneurysm. The risk area for thrombosis was concentrated in the expansion part of the aneurysm and the false lumen. The RRT and ECAP maxima of the double false lumen abdominal aortic dissection aneurysm were much greater than those of the single false lumen dissection aneurysm and saccular aortic aneurysm. CONCLUSION: Low-velocity blood flow, high OSI, low TAWSS, high RRT, and high ECAP regions correlate with the risk of thrombosis. The double false lumen type of abdominal aortic dissection aneurysm had some specificity in this case. The risk of thrombosis in the patient was extremely high, and the largest risk zone was within the smaller false lumen, which could be because the smaller false lumen was connected to the true lumen by only one breach. The results of the study provide some guidance in the early screening and development of treatment plans."

基金机构：Intelligent Medicine Research Project of Chongqing Medical University [YJSZHYX202110]

基金资助正文：This research was funded by the Intelligent Medicine Research Project of Chongqing Medical University (No. YJSZHYX202110).