INKA2-AS1 Is a Potential Promising Prognostic-Related Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma

作者全名："Li, Wenke; Hong, Guoqing; Lai, Xing"

作者地址："[Li, Wenke] Chongqing Med Univ, Yongchuan Hosp, Dept Hepatobiliary Surg, Chongqing, Peoples R China; [Hong, Guoqing; Lai, Xing] Tongnan Dist Peoples Hosp, Dept Hepatobiliary Surg, Chongqing, Peoples R China"

通信作者："Lai, X (通讯作者)，Tongnan Dist Peoples Hosp, Dept Hepatobiliary Surg, Chongqing, Peoples R China."

来源：MEDIATORS OF INFLAMMATION

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000988613900002

JCR分区：Q2

影响因子：4.4

年份：2023

卷号：2023

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Hepatocellular carcinoma (HCC) is a malignancy with one of the worst prognoses. Long noncoding RNAs (lncRNAs) may be important in cancer development and may serve as new biomarkers for the diagnosis and treatment of various tumors, according to mounting research. The purpose of this study was to investigate the expression of INKA2-AS1 and clinical importance in HCC patients. The TCGA database was used to obtain the human tumor samples, while the TCGA and GTEx databases were used to gather the human normal samples. We screened differentially expressed genes (DEGs) between HCC and nontumor tissues. Investigations were made into the statistical significance and clinical significance of INKA2-AS1 expression. A single-sample gene set enrichment analysis (ssGSEA) was used to examine potential relationships between immune cell infiltration and INKA2-AS1 expression. In this investigation, we found that HCC specimens had considerably greater levels of INKA2-AS1 expression than nontumor specimens. When utilizing the TCGA datasets and the GTEx database, high INKA2-AS1 expression showed an AUC value for HCC of 0.817 (95% confidence interval: 0.779 to 0.855). Pan-cancer assays revealed that numerous tumor types had dysregulated levels of INKA2-AS1. Gender, histologic grade, and pathologic stage were all substantially correlated with high INKA2-AS1 expression. A survival study indicated that HCC patients with high INKA2-AS1 expression have shorter OS, DSS, and PFI than those with low INKA2-AS1 expression. Multivariate analysis indicated that INKA2-AS1 expression was an independent prognostic factor for OS of patients with HCC. According to immune analysis, the expression of INKA2-AS1 was favorably correlated with T helper cells, Th2 cells, macrophages, TFH, and NK CD56bright cells and negatively correlated with Th17 cells, pDC, cytotoxic cells, DC, Treg, Tgd, and Tcm. The results of this study collectively suggest that INKA2-AS1 has the potential to be a novel biomarker for predicting the prognosis of HCC patients as well as a significant immune response regulator in HCC."

基金机构：Natural Science Foundation of Chongqing CSTC [cstc2020jcyj-msxmX0728]; Tongnan Bureau of Science and Technology

基金资助正文：This research was funded by the Natural Science Foundation of Chongqing CSTC (cstc2020jcyj-msxmX0728) and Tongnan Bureau of Science and Technology.