The associations between hematological parameters and the incidence of prehypertension and hypertension in children and adolescents: a prospective cohort study

作者全名："Huang, Lan; Song, Cui; Liu, Qin; Liang, Xiaoyue; Ren, Yanling; Huang, Daochao; Guan, Xianmin; An, Xizhou; Liang, Xiaohua"

作者地址："[Huang, Lan; Liu, Qin; Liang, Xiaoyue; Ren, Yanling; Huang, Daochao; Guan, Xianmin; An, Xizhou; Liang, Xiaohua] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Dept Clin Epidemiol & Biostat,Childrens Hosp,Chong, Chongqing 400014, Peoples R China; [Song, Cui] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Endocrinol & Genet Metab Dis,Childrens Hosp, Minist Educ Key Lab Child Dev & Disorders,Chongqin, Chongqing 400014, Peoples R China"

通信作者："Liang, XH (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Dept Clin Epidemiol & Biostat,Childrens Hosp,Chong, Chongqing 400014, Peoples R China."

来源：HYPERTENSION RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000988926400001

JCR分区：Q1

影响因子：4.3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Blood pressure; Red blood cell; Hemoglobin; Hematocrit; Iron

摘要："Uncontrolled pediatric hypertension may increase the risk of hypertension in adulthood. Several studies have reported an association between hematological parameters and blood pressure (BP) levels. However, epidemiologic evidence of this association in children and adolescents remains scarce. This study aims to explore the associations between hematological parameters and the incidence of prehypertension and hypertension in children and adolescents. This longitudinal study was conducted with 1368 participants aged 6-8 years from baseline visit to follow-up visit. Compared with participants from the normal blood pressure (BP) group, participants from the elevated BP group had significantly higher baseline red blood cell (RBC) counts, hemoglobin (Hb) counts and hematocrit (Hct) levels (all P < 0.001). A multilevel linear mixed model was conducted to analyze the relationship between hematological parameters and BP levels. The results suggested that SBP, DBP and MAP increased significantly with a quartile increase of levels of hematological parameters (all P < 0.05). Furthermore, a multilevel mixed logistic regression model was used to analyze the risk of per interquartile range increase in hematological parameters on the incidence of prehypertension and hypertension. The risk of prehypertension and hypertension incidence increased by (1.34 (95%CIs: 1.20, 1.50)), (1.38 (95%CIs: 1.24,1.54)), (1.33 (95%CIs: 1.19,1.50)), (1.14 (95%CIs: 1.03,1.26)) fold with a one-quartile increase in levels of RBC, Hb, Hct and Fe, respectively (all P < 0.05). This longitudinal study showed that hematological parameters were positively associated with BP levels in healthy children and adolescents, which excluded the effect of antihypertensive drugs on BP levels that often appeared in adults."

基金机构："National Clinical Research Center for Child Health and Disorders [NCRCCHD-2022-GP-01, NCRC-2020-GP-13, NCRCCHD-2020-GP-10]; Research and Innovation Team of Chongqing Medical University [W0088]; Chongqing Science and Technology Bureau [CSTC2021jscx-gksb-N0001]; Young and Middle-aged Medical Outstanding Expert Project of Chongqing Municipal Health Commission [78]; National Key Research and Development Project [2017YFC0211705]; Intelligent Medicine Project [ZHYX202109]; Natural Science Foundation of Youth Project [81502826]; Key project of Innovation and Development united Fund of Chongqing Natural Science Foundation [CSTB2022NSCQ-LZX0029]; Education Commission of Chongqing Municipality [KJQN201900443]"

基金资助正文："This work was supported by, National Clinical Research Center for Child Health and Disorders (No. NCRCCHD-2022-GP-01, NCRC-2020-GP-13, NCRCCHD-2020-GP-10), the Research and Innovation Team of Chongqing Medical University (No. W0088), Chongqing Science and Technology Bureau (No. CSTC2021jscx-gksb-N0001), Young and Middle-aged Medical Outstanding Expert Project of Chongqing Municipal Health Commission (No. 78), National Key Research and Development Project (No. 2017YFC0211705), Intelligent Medicine Project (No. ZHYX202109), Natural Science Foundation of Youth Project (No. 81502826), Key project of Innovation and Development united Fund of Chongqing Natural Science Foundation (CSTB2022NSCQ-LZX0029) and Education Commission of Chongqing Municipality (No. KJQN201900443). The funders had no role in the study design, the data collection and analysis, the decision to publish, or the preparation of the paper."