Prolonged Anesthesia Induction to Delivery Time Did Not Influence Plasma Remifentanil Concentration in Neonates

作者全名："Cai, Meng; Liu, Hao; Peng, Yong; Miao, Jing -Kun; Lei, Xiao-Feng; Yu, Jin"

作者地址："[Cai, Meng; Lei, Xiao-Feng; Yu, Jin] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Anesthesiol, 120 Longshan Rd, Chongqing 401147, Peoples R China; [Liu, Hao; Peng, Yong; Miao, Jing -Kun] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Pediat, Chongqing, Peoples R China"

通信作者："Yu, J (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Anesthesiol, 120 Longshan Rd, Chongqing 401147, Peoples R China."

来源：DRUG DESIGN DEVELOPMENT AND THERAPY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000989047800001

JCR分区：Q1

影响因子：4.7

年份：2023

卷号：17

期号：　

开始页：1395

结束页：1403

文献类型：Article

关键词：cesarean section; placental transport; general anesthesia; remifentanil; etomidate; drug concentration

摘要："Objective: Remifentanil, in combination with etomidate and sevoflurane, is commonly used in clinics for general anesthesia induction in cesarean section (CS). This study aimed to evaluate the correlation between the induction to delivery (I-D) time and neonatal plasma drug concentration and anesthesia, as well as its effects on neonates. Methods: Fifty-two parturients in whom general anesthesia was induced for CS were divided into group A (I-D<8 min) and group B (I-D >= 8 min). Maternal arterial (MA), umbilical venous (UV), and umbilical arterial (UA) blood samples were collected at delivery to analyze the remifentanil and etomidate concentrations using liquid chromatography-tandem mass spectrometry. Results: There were no statistically significant differences between the two groups in terms of plasma concentrations of remifentanil in the MA, UA, and UV blood (P > 0.05). The plasma concentration of etomidate in MA and UV was higher in group A than that in group B (P<0.05), whereas the UA/UV ratio of etomidate was higher in group B than that in group A (P<0.05). The Spearman rank correlation test showed no correlation between the I-D time and plasma remifentanil concentration in the MA, UA, and UV plasma (P>0.05). The concentrations of etomidate in the MA and UV were negatively correlated with the I-D time (P < 0.05). Conclusion: Prolonged I-D time did not significantly influence the maternal or neonatal plasma concentration of remifentanil. It is safe to administer remifentanil target-controlled infusion in combination with etomidate and sevoflurane for general anesthesia induction during CS."

基金机构：Natural Science Foundation of Chongqing of China [cstc2021jcyj-msxmX0763]; Chongqing Maternal and Child Health Scientific Research and Cultivation Project [2021FY106]; National Key Clinical Speciality Construction Project (Obstetrics and Gynecology)

基金资助正文："This study was supported by Natural Science Foundation of Chongqing of China (No. cstc2021jcyj-msxmX0763) and Chongqing Maternal and Child Health Scientific Research and Cultivation Project (No. 2021FY106) , National Key Clinical Speciality Construction Project (Obstetrics and Gynecology) ."