Vitamin D levels and the risk of overactive bladder: a systematic review and meta-analysis

作者全名："Zhang, Qiang; Zhang, Zhicheng; He, Xueyu; Liu, Zhenmin; Shen, Lianju; Long, Chunlan; Wei, Guanghui; Liu, Xing; Guo, Chunming"

作者地址："[Zhang, Qiang; Zhang, Zhicheng; He, Xueyu; Liu, Zhenmin; Shen, Lianju; Long, Chunlan; Wei, Guanghui; Liu, Xing; Guo, Chunming] Chongqing Med Univ, Childrens Hosp, Dept Urol, Chongqing, Peoples R China; [Zhang, Qiang; Zhang, Zhicheng; He, Xueyu; Liu, Zhenmin; Shen, Lianju; Long, Chunlan; Wei, Guanghui; Liu, Xing] Chongqing Med Univ, Childrens Hosp, Pediat Res Inst, Chongqing, Peoples R China; [Zhang, Qiang; Zhang, Zhicheng; He, Xueyu; Liu, Zhenmin; Shen, Lianju; Long, Chunlan; Wei, Guanghui; Liu, Xing] Chongqing Med Univ, Childrens Hosp,China Int Sci & Technol Cooperat Ba, Natl Clin Res Ctr Child Hlth & Disorders,Chongqing, Chongqing Key Lab Children Urogenital Dev & Tissue, Chongqing, Peoples R China; [Liu, Xing] Chongqing Med Univ, Program Youth Innovat Future Med, Chongqing, Peoples R China; [Guo, Chunming] Yunnan Univ, Sch Life Sci, Kunming, Peoples R China; [Liu, Xing] Chongqing Med Univ, Childrens Hosp, Dept Urol, Zhongshan Second Rd, Chongqing 400014, Peoples R China"

通信作者："Liu, X (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Urol, Zhongshan Second Rd, Chongqing 400014, Peoples R China."

来源：NUTRITION REVIEWS

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:000989473200001

JCR分区：Q1

影响因子：5.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：meta-analysis; overactive bladder; urinary incontinence; vitamin D levels; vitamin D supplementation

摘要："Context Overactive bladder is treated mainly with behavioral and drug therapy, and symptoms of urinary frequency and incontinence are challenging to eliminate. There is thus a continuous unmet need for new drugs with a substitution effect mechanism. Objective It not known whether vitamin D deficiency can lead to overactive bladder or urinary incontinence or whether vitamin D supplementation alleviates bladder symptoms. This comprehensive systematic review with meta-analysis was conducted to determine whether overactive bladder is associated with vitamin D deficiency. Data Sources The PubMed and Cochrane Library databases were searched systematically up to July 3, 2022. Data Extraction Initially, 706 articles were identified in the literature search, of which 13 were included in the systematic review: 4 randomized controlled trials, 3 cohort studies, 3 cross-sectional studies, and 3 case-control studies. Data Analysis An increased risk of overactive bladder and urinary incontinence was observed with vitamin D deficiency (odds ratio [OR] = 4.46; 95%CI, 1.03-19.33; P = 0.046 and OR = 1.30; 95%CI, 1.01-1.66; P = 0.036, respectively). Vitamin D levels were relatively low in patients with overactive bladder or urinary incontinence (SMD = -0.33; 95%CI, -0.61 to -0.06, P = 0.019). On the basis of existing data, the risk of urinary incontinence was reduced by 66% after vitamin D supplementation (OR = 0.34; 95%CI, 0.18-0.66; P = 0.001). Egger test was conducted to assess publication bias, and the results were tested for robustness using a sensitivity analysis. Conclusions Vitamin D deficiency increases the risk of overactive bladder and urinary incontinence, and vitamin D supplementation reduces the risk of urinary incontinence. The development of new strategies to prevent or alleviate bladder symptoms is crucial. Vitamin D supplementation may be gaining recognition as an effective strategy for prevention or alleviation of bladder symptoms such as overactive bladder and incontinence. Systematic Review Registration PROSPERO registration no. CRD42022351443."

基金机构：National Natural Science Foundation ofChina [81970571]

基金资助正文："The National Natural Science Foundation ofChina (No. 81970571, awarded to X.L.) provided funding for this work"