Humoral responses after primary and booster SARS-CoV-2 inactivated vaccination in patients with chronic hepatitis B virus infection: A longitudinal observational study

作者全名："Chen, Zhiwei; Huang, Tianquan; He, Taiyu; Zha, Guanhua; Zhu, Qian; Zhang, Gaoli; Xiang, Dejuan; Chen, Min; Li, Hu; Ling, Ning; Lan, Yinghua; Shi, Xiaofeng; Zhang, Dazhi; Xu, Pan; Pan, Qingbo; Song, Rui; Cao, Junxiong; Zhang, Yingzhi; Xiang, Hongyan; Feng, Yali; Yang, Ziqiao; Zhang, Biqiong; Shen, Wei; Cai, Dachuan; Peng, Mingli; Hu, Peng; Ren, Hong"

作者地址："[Chen, Zhiwei; Huang, Tianquan; He, Taiyu; Zha, Guanhua; Zhu, Qian; Zhang, Gaoli; Xiang, Dejuan; Chen, Min; Li, Hu; Ling, Ning; Lan, Yinghua; Shi, Xiaofeng; Zhang, Dazhi; Xu, Pan; Pan, Qingbo; Song, Rui; Cao, Junxiong; Zhang, Yingzhi; Xiang, Hongyan; Feng, Yali; Yang, Ziqiao; Zhang, Biqiong; Shen, Wei; Cai, Dachuan; Peng, Mingli; Hu, Peng; Ren, Hong] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis, Chongqing, Peoples R China; [Cai, Dachuan; Peng, Mingli; Hu, Peng; Ren, Hong] 288 Tianwen Ave, Chongqing 401336, Peoples R China"

通信作者："Cai, DC; Peng, ML; Hu, P; Ren, H (通讯作者)，288 Tianwen Ave, Chongqing 401336, Peoples R China."

来源：JOURNAL OF MEDICAL VIROLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000989594000036

JCR分区：Q1

影响因子：6.8

年份：2023

卷号：95

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：chronic hepatitis B virus infection; COVID-19; immunogenicity; inactivated vaccines; Omicron variants; SARS-CoV-2

摘要："Given the pandemic of severe acute respiratory syndrome coronavirus 2 Omicron variants, booster vaccination (BV) using inactivated virus vaccines (the third dose) has been implemented in China. However, the immune responses after BV, especially those against Omicron, in patients with chronic hepatitis B virus (HBV) infection (CHB) are unclear. In this prospective longitudinal study, 114 patients with CHB and 68 healthy controls (HCs) were recruited after receiving inactivated vaccination. The anti-receptor-binding domain (RBD) immunoglobulin G (IgG), neutralizing antibodies (NAbs), neutralization against Omicron (BA2.12.1, BA.4/5), and specific B/T cells were evaluated. In patients, anti-RBD IgG was elevated significantly after BV; the titers were as high as those in HCs. Similar results were obtained for the NAbs. However, compared with that against wild type (WT), the neutralization against Omicron was compromised after BV. The frequency of RBD+ atypical memory B cells increased, but spike-specific cluster of differentiation 4(+)/8(+) T cells remained unchanged after BV. Moreover, no serious adverse events or HBV reactivation were observed after BV. These results suggest that BV significantly enhanced antibody responses against WT; however, it resulted in compromised antibody responses against Omicron in patients with CHB. Hence, new all-in-one vaccines and optimal vaccination strategies should be studied promptly."

基金机构："National Science and Technology Major Project of China [2017ZX10202203-007, 2017ZX10202203-008, 2018ZX10302206-003]; National Natural Science Foundation of China [81772198]; Natural Science Foundation of Chongqing, China [cstc2020jcyj-msxmX0389]; pilot project of clinical cooperation between traditional Chinese and western medicine for significant and complicated diseases of National Administration of Traditional Chinese Medicine: hepatic fibrosis"

基金资助正文："National Science and Technology Major Project of China, Grant/Award Numbers: 2017ZX10202203-007, 2017ZX10202203-008, 2018ZX10302206-003; The pilot project of clinical cooperation between traditional Chinese and western medicine for significant and complicated diseases of National Administration of Traditional Chinese Medicine: hepatic fibrosis; National Natural Science Foundation of China, Grant/Award Number: 81772198; Natural Science Foundation of Chongqing, China, Grant/Award Number: cstc2020jcyj-msxmX0389"